Studying Human Neurodegenerative Diseases in Flies and Worms

Invertebrate models of several human neurodegenerative diseases have recently been described. These models faithfully replicate key neuropathological features of the human disorders. Because the basic cell biology of the nervous system is very similar in vertebrates and invertebrates, the sophistica...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2000-10, Vol.59 (10), p.847-856
Main Author: FEANY, MEL B
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caenorhabditis elegans
Degeneration
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Drosophila
Drosophila melanogaster
Genetic aspects
Humans
Medical sciences
Nervous system
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - physiopathology
Neurology
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Summary:Invertebrate models of several human neurodegenerative diseases have recently been described. These models faithfully replicate key neuropathological features of the human disorders. Because the basic cell biology of the nervous system is very similar in vertebrates and invertebrates, the sophisticated and rapid genetic analysis feasible in Drosophila and C. elegans promises significant insight into human neurodegenerative syndromes. In addition, the short lifespan, small size, and ease of culturing make worms and flies ideal for drug testing.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/59.10.847