Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation

Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activit...

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Bibliographic Details
Published in:International journal of cardiology 2000-09, Vol.75 (2), p.227-232
Main Authors: Mondillo, Sergio, Sabatini, Laura, Agricola, Eustachio, Ammaturo, Tiziana, Guerrini, Francesco, Barbati, Riccardo, Pastore, Monica, Fineschi, Daniela, Nami, Renato
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - pathology
Atrial Fibrillation - physiopathology
Biological and medical sciences
Biomarkers
Cardiac dysrhythmias
Cardiology. Vascular system
Chronic Disease
Endothelial dysfunction
Endothelium, Vascular
Female
Fibrinogen - analysis
Heart
Heart Atria - pathology
Hemodynamics
Humans
Hypercoagulability
Left atrium
Male
Medical sciences
Middle Aged
Nonrheumatic atrial fibrillation
Plasminogen Inactivators - analysis
Platelet Activation
von Willebrand Factor - analysis
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Summary:Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activity and markers of endothelial dysfunction in 45 patients with chronic nonrheumatic atrial fibrillation and in 35 controls. We assessed fibrinogen, antithrombin III, protein C, markers of platelet activation (platelet factor 4 and β-thromboglobulin) as markers of fibrinolysis, and D-dimer, tissue plasminogen activator, plasminogen activator inhibitor, von Willebrand’s factor and soluble thrombomodulin as endothelial dysfunction. Plasma fibrinogen ( P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(00)00336-3