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Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation
Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activit...
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| Published in: | International journal of cardiology 2000-09, Vol.75 (2), p.227-232 |
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| cites | cdi_FETCH-LOGICAL-c389t-608c39e4a1d8365e5d77083bc5b7077391510b75c4f905685614526d8ce99ea53 |
| container_end_page | 232 |
| container_issue | 2 |
| container_start_page | 227 |
| container_title | International journal of cardiology |
| container_volume | 75 |
| creator | Mondillo, Sergio Sabatini, Laura Agricola, Eustachio Ammaturo, Tiziana Guerrini, Francesco Barbati, Riccardo Pastore, Monica Fineschi, Daniela Nami, Renato |
| description | Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activity and markers of endothelial dysfunction in 45 patients with chronic nonrheumatic atrial fibrillation and in 35 controls. We assessed fibrinogen, antithrombin III, protein C, markers of platelet activation (platelet factor 4 and β-thromboglobulin) as markers of fibrinolysis, and D-dimer, tissue plasminogen activator, plasminogen activator inhibitor, von Willebrand’s factor and soluble thrombomodulin as endothelial dysfunction. Plasma fibrinogen (
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| doi_str_mv | 10.1016/S0167-5273(00)00336-3 |
| format | article |
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P<0.005), platelet factor 4 (
P<0.001), thromboglobulin (
P<0.001), D-dimer (
P<0.03), tissue plasminogen activator (
P<0.006), plasminogen activator inhibitor (
P<0.04) and both von Willebrand’s factor (
P<0.0001) and soluble thrombomodulin (
P<0.03) were significantly higher in the patients than in the controls. Positive significant linear correlations were found between fibrinogen and markers of endothelial dysfunction and left atrial volume and fibrinogen or markers of endothelial dysfunction. These findings confirm that chronic nonrheumatic atrial fibrillation is associated with a prothrombotic state but also suggest that there is a correlation between endothelial dysfunction, coagulation factors and left atrial dimension.]]></description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/S0167-5273(00)00336-3</identifier><identifier>PMID: 11077138</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Atrial Fibrillation - blood ; Atrial Fibrillation - pathology ; Atrial Fibrillation - physiopathology ; Biological and medical sciences ; Biomarkers ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Chronic Disease ; Endothelial dysfunction ; Endothelium, Vascular ; Female ; Fibrinogen - analysis ; Heart ; Heart Atria - pathology ; Hemodynamics ; Humans ; Hypercoagulability ; Left atrium ; Male ; Medical sciences ; Middle Aged ; Nonrheumatic atrial fibrillation ; Plasminogen Inactivators - analysis ; Platelet Activation ; von Willebrand Factor - analysis</subject><ispartof>International journal of cardiology, 2000-09, Vol.75 (2), p.227-232</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-608c39e4a1d8365e5d77083bc5b7077391510b75c4f905685614526d8ce99ea53</citedby><cites>FETCH-LOGICAL-c389t-608c39e4a1d8365e5d77083bc5b7077391510b75c4f905685614526d8ce99ea53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=811358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11077138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mondillo, Sergio</creatorcontrib><creatorcontrib>Sabatini, Laura</creatorcontrib><creatorcontrib>Agricola, Eustachio</creatorcontrib><creatorcontrib>Ammaturo, Tiziana</creatorcontrib><creatorcontrib>Guerrini, Francesco</creatorcontrib><creatorcontrib>Barbati, Riccardo</creatorcontrib><creatorcontrib>Pastore, Monica</creatorcontrib><creatorcontrib>Fineschi, Daniela</creatorcontrib><creatorcontrib>Nami, Renato</creatorcontrib><title>Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description><![CDATA[Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activity and markers of endothelial dysfunction in 45 patients with chronic nonrheumatic atrial fibrillation and in 35 controls. We assessed fibrinogen, antithrombin III, protein C, markers of platelet activation (platelet factor 4 and β-thromboglobulin) as markers of fibrinolysis, and D-dimer, tissue plasminogen activator, plasminogen activator inhibitor, von Willebrand’s factor and soluble thrombomodulin as endothelial dysfunction. Plasma fibrinogen (
P<0.005), platelet factor 4 (
P<0.001), thromboglobulin (
P<0.001), D-dimer (
P<0.03), tissue plasminogen activator (
P<0.006), plasminogen activator inhibitor (
P<0.04) and both von Willebrand’s factor (
P<0.0001) and soluble thrombomodulin (
P<0.03) were significantly higher in the patients than in the controls. Positive significant linear correlations were found between fibrinogen and markers of endothelial dysfunction and left atrial volume and fibrinogen or markers of endothelial dysfunction. These findings confirm that chronic nonrheumatic atrial fibrillation is associated with a prothrombotic state but also suggest that there is a correlation between endothelial dysfunction, coagulation factors and left atrial dimension.]]></description><subject>Aged</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - pathology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Chronic Disease</subject><subject>Endothelial dysfunction</subject><subject>Endothelium, Vascular</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Heart</subject><subject>Heart Atria - pathology</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Hypercoagulability</subject><subject>Left atrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nonrheumatic atrial fibrillation</subject><subject>Plasminogen Inactivators - analysis</subject><subject>Platelet Activation</subject><subject>von Willebrand Factor - analysis</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkVGL1DAUhYMo7rj6E5SAIApWbyZNkz7JMugqLPigPoc0vWWibTImqcv6Z_avms6U3UdfkpfvnHvvOYQ8Z_COAWvefyuPrMRW8tcAbwA4byr-gGyYknXFpKgfks0dckaepPQTAOq2VY_JGWMgJeNqQ253IUYcTXbB0w7zNaKnIw6ZmhydGWlyf_EtPcSQ9zFMXcjO0pRNRmp8TycTf2FMNAwUfV8YHBdRf5OG2dujqfP0UOzR50SvXd7TMXiktrj5YuWDj3ucJ7P4riMH10U3nnZ6Sh4NZkz4bP3PyY9PH7_vPldXXy-_7C6uKstVm6sGlOUt1ob1ijcCRS8lKN5Z0clyKm-ZYNBJYeuhBdEo0bBabJteWWxbNIKfk1cn33Lp7xlT1pNLFssWHsOctNzWjAtgBRQn0MaQUsRBH6IrMdxoBnppRh-b0UvsGkAfm9G86F6sA-Zuwv5etVZRgJcrYJI14xCNty7dcYqV-Qv14URhCeOPw6iTLdla7F1Em3Uf3H8W-QfZ_a2J</recordid><startdate>20000915</startdate><enddate>20000915</enddate><creator>Mondillo, Sergio</creator><creator>Sabatini, Laura</creator><creator>Agricola, Eustachio</creator><creator>Ammaturo, Tiziana</creator><creator>Guerrini, Francesco</creator><creator>Barbati, Riccardo</creator><creator>Pastore, Monica</creator><creator>Fineschi, Daniela</creator><creator>Nami, Renato</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000915</creationdate><title>Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation</title><author>Mondillo, Sergio ; Sabatini, Laura ; Agricola, Eustachio ; Ammaturo, Tiziana ; Guerrini, Francesco ; Barbati, Riccardo ; Pastore, Monica ; Fineschi, Daniela ; Nami, Renato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-608c39e4a1d8365e5d77083bc5b7077391510b75c4f905685614526d8ce99ea53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - pathology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Chronic Disease</topic><topic>Endothelial dysfunction</topic><topic>Endothelium, Vascular</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Heart</topic><topic>Heart Atria - pathology</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Hypercoagulability</topic><topic>Left atrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nonrheumatic atrial fibrillation</topic><topic>Plasminogen Inactivators - analysis</topic><topic>Platelet Activation</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mondillo, Sergio</creatorcontrib><creatorcontrib>Sabatini, Laura</creatorcontrib><creatorcontrib>Agricola, Eustachio</creatorcontrib><creatorcontrib>Ammaturo, Tiziana</creatorcontrib><creatorcontrib>Guerrini, Francesco</creatorcontrib><creatorcontrib>Barbati, Riccardo</creatorcontrib><creatorcontrib>Pastore, Monica</creatorcontrib><creatorcontrib>Fineschi, Daniela</creatorcontrib><creatorcontrib>Nami, Renato</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mondillo, Sergio</au><au>Sabatini, Laura</au><au>Agricola, Eustachio</au><au>Ammaturo, Tiziana</au><au>Guerrini, Francesco</au><au>Barbati, Riccardo</au><au>Pastore, Monica</au><au>Fineschi, Daniela</au><au>Nami, Renato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2000-09-15</date><risdate>2000</risdate><volume>75</volume><issue>2</issue><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract><![CDATA[Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activity and markers of endothelial dysfunction in 45 patients with chronic nonrheumatic atrial fibrillation and in 35 controls. We assessed fibrinogen, antithrombin III, protein C, markers of platelet activation (platelet factor 4 and β-thromboglobulin) as markers of fibrinolysis, and D-dimer, tissue plasminogen activator, plasminogen activator inhibitor, von Willebrand’s factor and soluble thrombomodulin as endothelial dysfunction. Plasma fibrinogen (
P<0.005), platelet factor 4 (
P<0.001), thromboglobulin (
P<0.001), D-dimer (
P<0.03), tissue plasminogen activator (
P<0.006), plasminogen activator inhibitor (
P<0.04) and both von Willebrand’s factor (
P<0.0001) and soluble thrombomodulin (
P<0.03) were significantly higher in the patients than in the controls. Positive significant linear correlations were found between fibrinogen and markers of endothelial dysfunction and left atrial volume and fibrinogen or markers of endothelial dysfunction. These findings confirm that chronic nonrheumatic atrial fibrillation is associated with a prothrombotic state but also suggest that there is a correlation between endothelial dysfunction, coagulation factors and left atrial dimension.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11077138</pmid><doi>10.1016/S0167-5273(00)00336-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of cardiology, 2000-09, Vol.75 (2), p.227-232 |
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| language | eng |
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| subjects | Aged Atrial Fibrillation - blood Atrial Fibrillation - pathology Atrial Fibrillation - physiopathology Biological and medical sciences Biomarkers Cardiac dysrhythmias Cardiology. Vascular system Chronic Disease Endothelial dysfunction Endothelium, Vascular Female Fibrinogen - analysis Heart Heart Atria - pathology Hemodynamics Humans Hypercoagulability Left atrium Male Medical sciences Middle Aged Nonrheumatic atrial fibrillation Plasminogen Inactivators - analysis Platelet Activation von Willebrand Factor - analysis |
| title | Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation |
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