Adherence of Aspergillus species to soft contact lenses and attempts to inhibit the adherence

The aim of this research was to assess the adherence of various Aspergillus species (A. niger, A. fumigatus, A. flavus) to contact lenses with different water content and to attempt to inhibit the adherence of Aspergillus spp. to the contact lenses by a chitin derivative (CSE). Adherence of Aspergil...

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Bibliographic Details
Published in:Mycoses 2001-12, Vol.44 (11-12), p.464-471
Main Authors: Sionov, E., Sandovsky-Losica, H., Gov, Y., Segal, Esther
Format: Article
Language:English
Subjects:
adherence
Adhärenz
Aspergillus
Aspergillus - physiology
Biological and medical sciences
Cell Adhesion - drug effects
Chitin - pharmacology
contact lenses
Contact Lenses - microbiology
Dose-Response Relationship, Drug
Human mycoses
Infectious diseases
Kontaktlinsen
Medical sciences
Miscellaneous mycoses
Mycoses
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Summary:The aim of this research was to assess the adherence of various Aspergillus species (A. niger, A. fumigatus, A. flavus) to contact lenses with different water content and to attempt to inhibit the adherence of Aspergillus spp. to the contact lenses by a chitin derivative (CSE). Adherence of Aspergillus spp. to lenses with higher water content was greater. Differences were found between the adherence levels of various Aspergillus species to contact lenses with different water content. CSE significantly inhibits the adherence in vitro of A. niger, A. fumigatus and A. flavus to soft contact lenses. These findings suggest a possibility for prevention of fungal ocular infections caused by Aspergillus spp. in wearers of contact lenses. Zusammenfassung.  Ziel der Studie war, die Adha¨renz von Aspergillus‐Arten (A. niger, A. fumigatus, A. flavus) an Kontaktlinsen unterschiedlichen Wassergehaltes und die Adha¨renzhemmung durch das Chitinderivat CSE zu pru¨fen. Die Adha¨renz nimmt mit dem Wassergehalt der Kontaktlinsen zu und ist abha¨ngig von der Aspergillus‐Spezies. CSE vermag die Aspergillus‐Adha¨renz an Kontaktlinsen signifikant zu hemmen. Das Ergebnis la¨sst die Mo¨glichkeit von Pra¨ventivmaßnahmen gegen Aspergillus‐Infektionen bei Kontaktlinsentra¨gern erhoffen.
ISSN:0933-7407
1439-0507
DOI:10.1046/j.1439-0507.2001.00694.x