New Pyrrolizidinone Antibiotics CJ-16, 264 and CJ-16, 367

Two new antibiotics, CJ-16, 264 (I) and CJ-16, 367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and...

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Bibliographic Details
Published in:Journal of antibiotics 2001/11/25, Vol.54(11), pp.917-925
Main Authors: SUGIE, YUTAKA, HIRAI, HIDEO, KACHI-TONAI, HIROKO, KIM, YOON-JEONG, KOJIMA, YASUHIRO, SHIOMI, YUKIO, SUGIURA, AKEMI, SUGIURA, AYUMU, SUZUKI, YUMIKO, YQSHIKAWA, NOBUJI, BRENNAN, LORI, DUIGNAN, JOAN, HUANG, LIANG HSIUNG, SUTCLIFFE, JOYCE, KOJIMA, NAKAO
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Drug Resistance, Multiple, Bacterial
Fermentation
Fundamental and applied biological sciences. Psychology
Fungi - chemistry
Fungi - cytology
Fungi - metabolism
Gas Chromatography-Mass Spectrometry
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
HeLa Cells - drug effects
Humans
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Microbial Sensitivity Tests
Microbiology
Molecular Weight
Nuclear Magnetic Resonance, Biomolecular
Optical Rotation
Pyrroles - chemistry
Pyrroles - isolation & purification
Pyrroles - pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Stereoisomerism
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Summary:Two new antibiotics, CJ-16, 264 (I) and CJ-16, 367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.917