Human papillomavirus infection of non-melanoma skin cancers in immunocompetent hosts

Human papilloma viruses (HPVs) consist of more than 70 different types and are known to be associated with numerous malignant tumors, including carcinomas of the mucosal and cutaneous epithelium. Non-melanoma skin carcinoma (NMSC) is the most frequently occurring malignancy worldwide in the Caucasia...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2000-12, Vol.161 (1), p.83-88
Main Authors: BILIRIS, K. A, KOUMANTAKIS, E, DOKIANAKIS, D. N, SOURVINOS, G, SPANDIDOS, D. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - immunology
Carcinoma, Basal Cell - virology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - virology
DNA, Neoplasm - genetics
DNA, Viral - genetics
Globins - genetics
Human papillomavirus
Humans
Immunocompetence
Medical sciences
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomavirus Infections - immunology
Papillomavirus Infections - virology
Polymerase Chain Reaction - methods
Precancerous Conditions - genetics
Precancerous Conditions - immunology
Precancerous Conditions - virology
skin cancer
Skin Neoplasms - genetics
Skin Neoplasms - immunology
Skin Neoplasms - virology
Tumor Virus Infections - immunology
Tumor Virus Infections - virology
Tumors
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human papilloma viruses (HPVs) consist of more than 70 different types and are known to be associated with numerous malignant tumors, including carcinomas of the mucosal and cutaneous epithelium. Non-melanoma skin carcinoma (NMSC) is the most frequently occurring malignancy worldwide in the Caucasian population. Most studies examining the involvement of papillomaviruses in the development of cutaneous carcinomas have been performed on lesions from patients with epidermodysplasia verruciformis or from immunosuppressed patients. Our specimens were obtained from 108 immunocompetent patients with benign and malignant skin lesions, and HPVs were detected in 27%. HPV 8 and HPV 18 were the most frequent types (62 and 48%, respectively). Our results suggest that HPVs, particularly the oncogenic potential of certain types such as HPV 8, 18, and 5 could contribute to the development of NMSCs.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00596-6