Molecular domains of myelinated axons

Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na + channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K + channels and Caspr2 in the juxtaparanodal regi...

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Bibliographic Details
Published in:Current Opinion in Neurobiology 2000-10, Vol.10 (5), p.558-565
Main Authors: Peles, Elior, Salzer, James L
Format: Article
Language:English
Subjects:
Animals
ankyrin G
Axons - chemistry
Axons - metabolism
Axons - ultrastructure
Caspr
contactin
Humans
Ion Channels - metabolism
Ion Channels - physiology
microdomains
Myelin Sheath - chemistry
Myelin Sheath - metabolism
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - metabolism
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Summary:Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na + channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K + channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged.
ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(00)00122-7