Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase

A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-11, Vol.10 (22), p.2513-2516
Main Authors: Dankwardt, Sharon M, Billedeau, Roland J, Lawley, Linda K, Abbot, Sarah C, Martin, Robert L, Chan, Christine S, Van Wart, Harold E, Walker, Keith A.M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Bone Morphogenetic Protein 1
Bone Morphogenetic Proteins - antagonists & inhibitors
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Hydrolases
Hydroxamic Acids - chemical synthesis
Hydroxamic Acids - chemistry
Hydroxamic Acids - pharmacology
Metalloendopeptidases - antagonists & inhibitors
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Description
Summary:A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00525-4