Glycyrrhizin Inhibits the Lytic Pathway of Complement - Possible Mechanism of Its Anti-Inflammatory Effect on Liver Cells in Viral Hepatitis

Glycyrrhizin, an aqueous extract of licorice root, has anti‐inflammatory activity and has been used for the treatment of chronic viral hepatitis. In the present study we describe the mechanism by which glycyrrhizin inhibits complement. Glycyrrhizin inhibited the cytolytic activity of complement via...

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Published in:Microbiology and immunology 2000-01, Vol.44 (9), p.799-804
Main Authors: Fujisawa, Yumiko, Sakamoto, Motoko, Matsushita, Misao, Fujita, Teizo, Nishioka, Kusuya
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
complement
Complement Inactivator Proteins - pharmacology
Complement Membrane Attack Complex - antagonists & inhibitors
Glycyrrhizic Acid - pharmacology
Glycyrrhizin
Guinea Pigs
Hepatitis, Viral, Human - drug therapy
Hepatocytes - drug effects
Humans
lytic pathway
Medical sciences
Pharmacology. Drug treatments
Sheep
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description Glycyrrhizin, an aqueous extract of licorice root, has anti‐inflammatory activity and has been used for the treatment of chronic viral hepatitis. In the present study we describe the mechanism by which glycyrrhizin inhibits complement. Glycyrrhizin inhibited the cytolytic activity of complement via the activation of both the classical and alternative pathways, while it had no effect on immune adherence, suggesting that it blocks C5 or a later stage of the complement cascade. Further analysis revealed that glycyrrhizin inhibits the lytic pathway in which the membrane attack complex (MAC) is formed. This mechanism suggests that glycyrrhizin may prevent tissue injury caused by MAC not only in chronic hepatitis but in many autoimmune and inflammatory diseases.
doi_str_mv 10.1111/j.1348-0421.2000.tb02566.x
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source Alma/SFX Local Collection
subjects Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
complement
Complement Inactivator Proteins - pharmacology
Complement Membrane Attack Complex - antagonists & inhibitors
Glycyrrhizic Acid - pharmacology
Glycyrrhizin
Guinea Pigs
Hepatitis, Viral, Human - drug therapy
Hepatocytes - drug effects
Humans
lytic pathway
Medical sciences
Pharmacology. Drug treatments
Sheep
title Glycyrrhizin Inhibits the Lytic Pathway of Complement - Possible Mechanism of Its Anti-Inflammatory Effect on Liver Cells in Viral Hepatitis
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