Platelet monoamine oxidase B activity is inversely associated with plasma cotinine concentration

Cigarette smoke but not nicotine inhibits irreversibly platelet monoamine oxidase B (MAO-B) activity. Current smokers have decreased platelet MAO-B activity which normalizes when smokers quit. Normalization of platelet MAO-B activity probably depends on platelet turnover. Platelet MAO-B activity has...

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Bibliographic Details
Published in:Nicotine & tobacco research 2000-08, Vol.2 (3), p.243-246
Main Authors: Berlin, Ivan, Spreux-Varoquaux, Odile, Launay, Jean-Marie
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
amine oxidase (flavin-containing)
Biological and medical sciences
Blood Platelets - enzymology
Cotinine - blood
Female
Humans
Male
Medical sciences
Middle Aged
Monoamine Oxidase - metabolism
Regression Analysis
Sex Factors
Smoking - blood
Tobacco, tobacco smoking
Toxicology
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Summary:Cigarette smoke but not nicotine inhibits irreversibly platelet monoamine oxidase B (MAO-B) activity. Current smokers have decreased platelet MAO-B activity which normalizes when smokers quit. Normalization of platelet MAO-B activity probably depends on platelet turnover. Platelet MAO-B activity has been found to be correlated with plasma thiocyanate concentration. The aim of this study was to investigate in smokers whether platelet MAO-B activity is related to plasma cotinine concentration, an indirect index of use of smoked tobacco. We determined simultaneously plasma cotinine concentration and platelet MAO-B activity in 85 cigarette smokers [mean (±SD) age 39 ± 8.8 years, 55 men]. Platelet MAO-B activity was lower in male than in female smokers (14.1 ± 7.9 versus 17.8 ± 7.2 nmol/h/109 platelets, p = 0.03). Platelet MAO-B activity correlated positively with age (r = 0.26, p = 0.01) and inversely with plasma cotinine concentration (r = −0.32, p = 0.002) but not with number of cigarettes smoked or with Fagerström Tolerance Questionnaire score. Multiple linear regression analysis showed that 49% of the age-adjusted variance in platelet MAO-B activity (R2 = 0.489, p
ISSN:1462-2203
1469-994X
DOI:10.1080/14622200050147501