Genetic risk factors of sporadic Alzheimer’s disease among Chinese in Taiwan

• Published in: Journal of the neurological sciences 2000-12, Vol.181 (1), p.127-131
• Main Authors: Hu, Chaur-Jong, Sung, Shing-Ming, Liu, Hsing-Cheng, Hsu, Wei-Chen, Lee, Long-Shyong, Lee, Cheng-Chun, Tsai, Chang-Hai, Chang, Jan-Gowth
• Format: Article
• Language: English
• Subjects: Aged - physiology; Aged - statistics & numerical data; Aged, 80 and over; Alzheimer Disease - ethnology; Alzheimer Disease - genetics; Alzheimer’s disease; Apolipoprotein E4; Apolipoproteins E - genetics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Chinese; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; DNA Mutational Analysis - statistics & numerical data; Female; Gene Frequency - genetics; Genetics; Genotype; Humans; Male; Medical sciences; Middle Aged; Neurology; Polymorphism, Genetic - genetics; Risk Factors; Taiwan; Tropical medicine
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/S0022-510X(00)00443-3

To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer’s disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of α 2-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and α 1-antichymotrypsin gene (ACT, −15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese. Eighty-two AD patients and 110 non-affected individuals were recruited for this study. We used polymerase chain reaction (PCR) and restriction enzyme digestion to identify their genotypes. The statistical examination was performed by combining the results of our previous reports — apolipoprotein E ϵ4 (ApoE-4), presenilin-1 intronic polymorphism (PS-1, allele 1/2), and the five-nucleotide deletion of α 2-macroglobulin gene (A2M). Among these nine candidate genes of AD, the ApoE-4 allele is the only independent genetic risk factor for AD. The other candidate genes in this study were not associated with the occurrence of AD. In addition, there are no gene–gene interactions.