Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation

1  Abteilungen für Pathophysiologie, 2  Hämatologie, und 3  Kardiologie, Zentrum für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany A close relationship exists between regional myocardial blood flow (RMBF) and function during acute coronary inflow restriction (perfusion-contraction m...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-12, Vol.279 (6), p.H2587-H2592
Main Authors: Dorge, Hilmar, Neumann, Till, Behrends, Matthias, Skyschally, Andreas, Schulz, Rainer, Kasper, Christoph, Erbel, Raimund, Heusch, Gerd
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Blood Pressure
Chemotaxis, Leukocyte - immunology
Coronary Circulation - immunology
Dogs
Embolism - immunology
Embolism - pathology
Embolism - physiopathology
Heart Rate
Leukocyte Count
Leukocytes - cytology
Leukocytes - immunology
Macrophages - cytology
Macrophages - immunology
Microcirculation - immunology
Microspheres
Monocytes - cytology
Monocytes - immunology
Myocardial Contraction - immunology
Myocardial Stunning - immunology
Myocardial Stunning - pathology
Myocardial Stunning - physiopathology
Myocarditis - immunology
Myocarditis - pathology
Myocarditis - physiopathology
Pericardium - immunology
Pericardium - pathology
Pericardium - physiopathology
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Summary:1  Abteilungen für Pathophysiologie, 2  Hämatologie, und 3  Kardiologie, Zentrum für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany A close relationship exists between regional myocardial blood flow (RMBF) and function during acute coronary inflow restriction (perfusion-contraction matching). However, the relationship of flow and function during coronary microvascular obstruction is unknown. In 12 anesthetized dogs, the left circumflex coronary artery was perfused from an extracorporeal circuit. After control measurements, 3,000 microspheres (42 µm diameter) per milliliter per minute inflow were injected to cause a microembolism (ME, n  = 6). With unchanged systemic hemodynamics and RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and 6.9 ± 4.7% ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2000.279.6.H2587