Translational regulation as a novel mechanism for the development of cellular drug resistance

Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synt...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2001-01, Vol.20 (1-2), p.33-41
Main Authors: Schmitz, J C, Liu, J, Lin, X, Chen, T M, Yan, W, Tai, N, Gollerkeri, A, Chu, E
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Cells
Chemotherapy
Drug resistance
Drug Resistance, Neoplasm
Gene Expression Regulation, Enzymologic - physiology
Genetics
Humans
Neoplasms - drug therapy
Neoplasms - enzymology
Protein Biosynthesis
Tetrahydrofolate Dehydrogenase - genetics
Tetrahydrofolate Dehydrogenase - metabolism
Thymidylate Synthase - genetics
Thymidylate Synthase - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Summary:Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.
ISSN:0167-7659
1573-7233
DOI:10.1023/A:1013100306315