Effect of epitalon on the lifespan increase in Drosophila melanogaster

The geroprotector activity of epitalon, a synthetic tetrapeptide Ala–Glu–Asp–Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva). Epitalon significantly increased the lifespan (LS) of...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2000-12, Vol.120 (1), p.141-149
Main Authors: Khavinson, V.Kh, Izmaylov, D.M., Obukhova, L.K., Malinin, V.V.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Dose-Response Relationship, Drug
Drosophila melanogaster
Drosophila melanogaster - drug effects
Drosophila melanogaster - growth & development
Epitalon
Female
Lifespan
Longevity - drug effects
Male
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Sex Characteristics
Ultralow concentrations
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Summary:The geroprotector activity of epitalon, a synthetic tetrapeptide Ala–Glu–Asp–Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva). Epitalon significantly increased the lifespan (LS) of imagoes by 11–16% when applied at unprecedented low concentrations — from 0.001×10 –6 to 5×10 –6 wt.% of culture medium for males and from 0.01×10 –6 to 0.1×10 –6 wt.% of culture medium for females. The increase in LS did not depend on the substance dose. Effective concentrations of epitalon were 16 000–80 000 000 times lower than those of melatonin. The possible mechanisms of the antioxidant and regulatory effects of epitalon are discussed.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(00)00217-7