Augmentation with sulpiride for a schizophrenic patient partially responsive to clozapine

Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies. Single case repor...

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Bibliographic Details
Published in:Acta psychiatrica Scandinavica 2000-11, Vol.102 (5), p.390-394
Main Authors: STUBBS, Jean H, HAW, Camilla M, STALEY, Christopher J, MOUNTJOY, Christopher Q
Format: Article
Language:English
Subjects:
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Clozapine - administration & dosage
Clozapine - therapeutic use
Drug Therapy, Combination
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Randomized Controlled Trials as Topic
Schizophrenia, Paranoid - drug therapy
Sulpiride - administration & dosage
Sulpiride - therapeutic use
Treatment Outcome
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Summary:Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies. Single case report and literature review. The total number of patients in studies and case reports of combining clozapine with other antipsychotics is small. There has been only one randomized controlled trial. This found the addition of sulpiride to clozapine resulted in clinical improvement in some patients. Further randomized controlled studies of augmentation of clozapine therapy are needed to provide scientific justification for this clinical practice.
ISSN:0001-690X
1600-0447
DOI:10.1034/j.1600-0447.2000.102005390.x