Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas

We assayed thymidine kinase (TK) and cathepsin D (Cath-D) in 200 breast carcinomas and we found that they were significantly correlated. This correlation was present in lymph node positive tumours, in G2 and G3, in T1 and in invasive ductal carcinomas. In addition, TK and Cath-D did not correlate wi...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2000-11, Vol.160 (1), p.13-19
Main Authors: Greco, S, Marsigliante, S, Leo, G, Storelli, C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Cathepsin D
Cathepsin D - metabolism
Female
Gynecology. Andrology. Obstetrics
Humans
Lymph Nodes - pathology
Mammary gland diseases
Medical sciences
Menopause
Middle Aged
Neoplasm Invasiveness
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Statistics as Topic
Steroid receptors
Thymidine kinase
Thymidine Kinase - metabolism
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We assayed thymidine kinase (TK) and cathepsin D (Cath-D) in 200 breast carcinomas and we found that they were significantly correlated. This correlation was present in lymph node positive tumours, in G2 and G3, in T1 and in invasive ductal carcinomas. In addition, TK and Cath-D did not correlate with oestrogen receptor (ER) and progesterone receptor (PgR) status. We conclude that the relationship between Cath-D and TK may indicate a tumour population of high proliferation activity and invasiveness potential, related to a more aggressive phenotype, whose identification may be useful in defining prognosis.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00550-4