Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine

To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by...

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Bibliographic Details
Published in:British journal of haematology 2000-10, Vol.111 (1), p.112-117
Main Authors: ROSEBOOM, T. J, VAN DER MEULEN, J. H. P, RAVELLI, A. C. J, OSMOND, C, BARKER, D. J. P, BLEKER, O. P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth Weight
Body Mass Index
Case-Control Studies
Diseases of mother, fetus and pregnancy
Factor VII - analysis
Female
Fetal Growth Retardation - blood
Fibrinogen - analysis
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Hematology
Humans
Liver - metabolism
Medical sciences
Middle Aged
Nutrition Disorders - blood
Nutrition Disorders - complications
Placenta - anatomy & histology
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Pregnancy. Fetus. Placenta
Prenatal exposure
Prenatal Exposure Delayed Effects
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Summary:To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by -0.01 g/l (95% confidence interval, -0.14-0.11) in those exposed in late gestation, by -0.03 g/l (-0.16-0.11) in those exposed in mid gestation, and by 0.13 g/l (-0.03-0.30) in those exposed in early gestation, compared with non-exposed people (those born before and those conceived after the famine pooled together). Plasma factor VII concentrations differed by 0.4% (-5.4% to 6.6%) in those exposed to famine in late gestation, by 1.5% (-4.6% to 8.1%) in those exposed in mid gestation. and by -11.8% (-18.4 to -4.8%) in those exposed in early gestation, compared with nonexposed people. Size at birth was not associated with plasma concentrations of fibrinogen or factor VII. Our finding that factor VII concentrations were significantly lower in people whose mothers had been exposed to famine in early pregnancy suggests that liver function may be affected by undernutrition in early gestation.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02268.x