Hydrodynamic effects on the solute transport across endothelial pores and hepatocyte membranes

In this short note we propose a simple and rapid procedure to calculate the net quantity of metabolites absorbed by hepatocytes from blood plasma. The blood movement through sinusoids determines an opposed circulation of plasma through the space of Disse. Hydrodynamic considerations lead to the conc...

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Bibliographic Details
Published in:Physics in medicine & biology 2000-11, Vol.45 (11), p.N157-N165
Main Authors: Popescu, Dumitru, Movileanu, Liviu, Ion, Stelian, Flonta, Maria-Luiza
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood - metabolism
Cell Membrane - metabolism
Cell Membrane - physiology
Cell physiology
Chylomicrons - metabolism
Computer Simulation
Endothelium - metabolism
Endothelium - physiology
Fundamental and applied biological sciences. Psychology
Hepatocytes - metabolism
Hepatocytes - physiology
Liver - metabolism
Membrane and intracellular transports
Models, Theoretical
Molecular and cellular biology
Rats
Temperature
Water - metabolism
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Summary:In this short note we propose a simple and rapid procedure to calculate the net quantity of metabolites absorbed by hepatocytes from blood plasma. The blood movement through sinusoids determines an opposed circulation of plasma through the space of Disse. Hydrodynamic considerations lead to the conclusion that hepatocytes absorb for their own synthesis processes a quantity of metabolites in a volume flow of the order of 10(-12) nl s(-1) through a sieve plate surface with an area of 1 microm2. At pathological temperature (40 degrees C), the excess of the net absorbed volume flow for the entire sinusoidal surface of the mammalian liver may be as high as 1.9 nl s(-1). Some observations on the effect of red and white blood cells on the chylomicron traffic through endothelial pores are made.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/45/11/404