PASS: prediction of activity spectra for biologically active substances

The concept of the biological activity spectrum was introduced to describe the properties of biologically active substances. The PASS (prediction of activity spectra for substances) software product, which predicts more than 300 pharmacological effects and biochemical mechanisms on the basis of the...

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Bibliographic Details
Published in:Bioinformatics 2000-08, Vol.16 (8), p.747-748
Main Authors: Lagunin, Alexey, Stepanchikova, Alla, Filimonov, Dmitrii, Poroikov, Vladimir
Format: Article
Language:English
Subjects:
biologically active substances
Drug Design
Drug Evaluation, Preclinical
Internet
Software
Structure-Activity Relationship
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Summary:The concept of the biological activity spectrum was introduced to describe the properties of biologically active substances. The PASS (prediction of activity spectra for substances) software product, which predicts more than 300 pharmacological effects and biochemical mechanisms on the basis of the structural formula of a substance, may be efficiently used to find new targets (mechanisms) for some ligands and, conversely, to reveal new ligands for some biological targets. We have developed a WWW interface for the PASS software. A WWW server for the on-line prediction of the biological activity spectra of substances has been constructed. Availability: http://www.ibmh.msk.su/PASS/ Contact: pass@ibmh.msk.su
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/16.8.747