Novelties in the Field of Anti-Infective Compounds in 1999

In 1999 the number of new compounds reported in the anti-infective field decreased significantly in comparison with previous years, especially for antifungals. The reported new compounds are mainly directed against Staphylococcus aureus isolates resistant to methicillin. Few derivatives were reporte...

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Bibliographic Details
Published in:Clinical infectious diseases 2000-12, Vol.31 (6), p.1423-1466
Main Author: Bryskier, André
Format: Article
Language:English
Subjects:
American culture
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterials
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Bacteria - drug effects
Biological and medical sciences
Carbapenems
Chemotherapy
Drugs, Investigational - chemistry
Drugs, Investigational - pharmacology
Drugs, Investigational - therapeutic use
Eukaryota - drug effects
Fluoroquinolones
Gram positive cocci
Humans
Infection - drug therapy
Ketolides
Medical sciences
Microbiology
Miscellaneous. Antibiotics with multiple activities
Penicillin
Pharmacology. Drug treatments
Special Section: Clinical Practice
Staphylococcus aureus
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Summary:In 1999 the number of new compounds reported in the anti-infective field decreased significantly in comparison with previous years, especially for antifungals. The reported new compounds are mainly directed against Staphylococcus aureus isolates resistant to methicillin. Few derivatives were reported in the field of anti-infectives for gram-negative bacteria. At the moment, we are in a period of discovery as we await novel compounds that could issue from new engineering.
ISSN:1058-4838
1537-6591
DOI:10.1086/317490