Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome

Serotonin transporters (SERTs) are presynaptic proteins specialized for the clearance of serotonin from the synaptic cleft. A large body of evidence exists on altered platelet serotonin uptake and metabolism in Down syndrome (DS). Besides, dysregulation of SERTs expression have been reported in vari...

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Bibliographic Details
Published in:Neuroscience letters 2000-12, Vol.296 (1), p.53-57
Main Authors: Gulesserian, Talin, Engidawork, Ephrem, Cairns, Nigel, Lubec, Gert
Format: Article
Language:English
Subjects:
Adult
Alzheimer Disease - metabolism
Alzheimer's diseases
Biological and medical sciences
Brain
Carrier Proteins - metabolism
Cerebellum - metabolism
Chromosome aberrations
Down syndrome
Down Syndrome - metabolism
Female
Frontal Lobe - metabolism
Humans
Immunoreactivity
Male
Medical genetics
Medical sciences
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Middle Aged
Nerve Tissue Proteins
Neuron specific enolase
Phosphopyruvate Hydratase - metabolism
Reference Values
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins
Serotonin transporter
Western blotting
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Summary:Serotonin transporters (SERTs) are presynaptic proteins specialized for the clearance of serotonin from the synaptic cleft. A large body of evidence exists on altered platelet serotonin uptake and metabolism in Down syndrome (DS). Besides, dysregulation of SERTs expression have been reported in various complex behavioural traits and disorders including, neurodegenerative disorders. This prompted us to investigate SERT protein levels in adult brain specimens. Western blot analyses were performed in frontal cortex and cerebellum of aged controls and patients with DS and Alzheimer's disease (AD). The result revealed that frontal cortex SERT was significantly increased ( P
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01624-4