CADASIL: the dermatologic diagnosis of a neurologic disease. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an increasingly recognized neurologic disease characterized by pathognomonic changes to the small vessels, particularly in the brain and skin. Although much has recently been written about this di...

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Published in:Journal of the American Academy of Dermatology 2000-12, Vol.43 (6), p.1128-1130
Main Authors: Rumbaugh, J A, LaDuca, J R, Shan, Y, Miller, C A
Format: Article
Language:English
Subjects:
Biopsy, Needle
Dementia, Multi-Infarct - diagnosis
Dementia, Multi-Infarct - pathology
Dermatology
Humans
Immunohistochemistry
Microscopy, Electron
Muscle, Smooth, Vascular - ultrastructure
Sensitivity and Specificity
Skin - pathology
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container_title Journal of the American Academy of Dermatology
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creator Rumbaugh, J A
LaDuca, J R
Shan, Y
Miller, C A
description Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an increasingly recognized neurologic disease characterized by pathognomonic changes to the small vessels, particularly in the brain and skin. Although much has recently been written about this disease in the neuropathology literature, to our knowledge nothing has appeared in the dermatology literature. We wish to call attention to the unique role dermatologists and dermatopathologists can play in the diagnosis of this disease. We review the condition's clinical, histologic, and ultrastructural features.
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subjects Biopsy, Needle
Dementia, Multi-Infarct - diagnosis
Dementia, Multi-Infarct - pathology
Dermatology
Humans
Immunohistochemistry
Microscopy, Electron
Muscle, Smooth, Vascular - ultrastructure
Sensitivity and Specificity
Skin - pathology
title CADASIL: the dermatologic diagnosis of a neurologic disease. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
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