In vivo drug target discovery: identifying the best targets from the genome

A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function i...

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Bibliographic Details
Published in:Current Opinion in Biotechnology 2001-12, Vol.12 (6), p.626-631
Main Authors: Walke, D.Wade, Han, Chunsheng, Shaw, Joseph, Wann, Elisabeth, Zambrowicz, Brian, Sands, Arthur
Format: Article
Language:English
Subjects:
Animals
Automation
Computational Biology
drug discovery
Drug Industry - methods
drug target
Gene Library
Genetic Techniques
Genome
high-throughput
Humans
Mice
Mice, Knockout
Mouse gene knockout
Phenotype
phenotypic screening
Software
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Summary:A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.
ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(01)00271-3