Concentration of Tc-99m MDP in Ovarian Carcinoma and Its Soft Tissue Metastases

A patient with ovarian carcinoma was evaluated for skeletal metastasis with a routine whole body bone scan. Although no bone metastases were visualized, there was dramatic accumulation of tracer in the soft tissues of the abdomen. CT revealed calcifying soft tissue metastases on the liver surface, t...

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Bibliographic Details
Published in:Clinical nuclear medicine 1991-08, Vol.16 (8), p.550-552
Main Authors: BERES, ROBERT A, PATEL, NEETIN, KRASNOW, ARTHUR Z, ISITMAN, ALI T, HELLMAN, ROBERT S, VELUVOLU, PURUSHOTHAM, PATILLO, RONALD S, COLLIER, B DAVID
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - diagnostic imaging
Abdominal Neoplasms - secondary
Adult
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Carcinoma, Papillary - diagnostic imaging
Carcinoma, Papillary - secondary
Female
Humans
Ovarian Neoplasms - pathology
Radionuclide Imaging
Soft Tissue Neoplasms - diagnostic imaging
Soft Tissue Neoplasms - secondary
Technetium Tc 99m Medronate
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Summary:A patient with ovarian carcinoma was evaluated for skeletal metastasis with a routine whole body bone scan. Although no bone metastases were visualized, there was dramatic accumulation of tracer in the soft tissues of the abdomen. CT revealed calcifying soft tissue metastases on the liver surface, the bowel serosa, and in the pelvis corresponding to the abnormal areas of Tc-99m MDP uptake. Tumor necrosis and ongoing calcification within the metastatic sites are possible explanations for this unusual soft tissue concentration of the bone-seeking radiopharmaceutical. In patlents with meatastatic ovarian carcinoma, careful review of extraosseous regions on bone scan images may provide valuable diagnostic information.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199108000-00003