Primary Hyperoxaluria Type 1 Bone Scintigraphy, X-ray Radiography, and Gamma-ray Quantitative CT

A 34-year old man presented with primary hyperoxaluria type 1. Primary hyperoxaluria is a rare autosomal recessive inherited disorder. Type 1 shows an excessive synthesis of calcium oxalate and glycolate resulting from a block of the metabolism precursor, glycolate. The disease is characterized by r...

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Bibliographic Details
Published in:Clinical nuclear medicine 1991-09, Vol.16 (9), p.681-683
Main Authors: SCHNEIDER, PETER, RENDL, JOHANN, BÖRNER, WiLHELM, HEIDBREDER, EKKEHART
Format: Article
Language:English
Subjects:
Adult
Bone and Bones - diagnostic imaging
Humans
Hyperoxaluria, Primary - diagnostic imaging
Male
Radiography
Technetium Tc 99m Medronate
Tomography, Emission-Computed
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Summary:A 34-year old man presented with primary hyperoxaluria type 1. Primary hyperoxaluria is a rare autosomal recessive inherited disorder. Type 1 shows an excessive synthesis of calcium oxalate and glycolate resulting from a block of the metabolism precursor, glycolate. The disease is characterized by recurrent calcium oxalate nephrolithiasis and chronic renal failure and leads to early death due to the complications. The extreme oxalate production also causes extrarenal deposits of calcium oxalate, namely in the Haversian system of bone, bone marrow, joints, heart, vascular system, and almost all other organs. In this patient, skeletal scintigraphy and bone densitometry contributed to the final diagnosis. First osteomalacia was suspected due to radiological and clinical findings. The diagnosis was based on definite clinical findings and the oxalic acid serum level. Serum level of oxalic acid was found to be 153.3 umol/l (normal
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199109000-00017