The involvement of the neuronal Golgi apparatus and trans-Golgi network in the human olivary hypertrophy

We studied the Golgi apparatus (GA) and trans-Golgi network (TGN) in the human olivary hypertrophy by immunohistological methods with organelle specific antibodies against the medial cisternae of the organelle (MG160) and the trans-Golgi network (TGN46). The GA and TGN of enlarged neurons in the inf...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 2000-12, Vol.182 (1), p.45-50
Main Authors: Takamine, Kazuo, Okamoto, Koichi, Fujita, Yukio, Sakurai, Atsushi, Takatama, Masamitsu, Gonatas, Nicholas K.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Golgi apparatus
Golgi Apparatus - pathology
Humans
Hypertrophy - pathology
Male
Medical sciences
MG160
Middle Aged
Multiple system atrophy
Neurology
Neurons - pathology
Olivary hypertrophy
Olivary Nucleus - pathology
Pathology
Trans-Golgi network
trans-Golgi Network - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the Golgi apparatus (GA) and trans-Golgi network (TGN) in the human olivary hypertrophy by immunohistological methods with organelle specific antibodies against the medial cisternae of the organelle (MG160) and the trans-Golgi network (TGN46). The GA and TGN of enlarged neurons in the inferior olivary nuclei in the early stages after central tract lesions lost the normal network-like configuration, and they were reduced to numerous small disconnected granules (fragmentation). In chronic stages after lesions, the GA and TGN of vacuolated or enlarged neurons showed a variety of morphological profiles, such as normal-looking patterns, fragmentation, reduction in number, and aggregation around nuclei or at a distance in the cytoplasm. In patients with multiple system atrophy, the GA and TGN of the neurons in the inferior olivary nuclei showed almost similar findings to those seen in the chronic stages after brainstem lesions. These results suggest that the GA and TGN are affected in degenerating neurons by anterograde transneuronal mechanisms.
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(00)00447-0