Induction of an endothelial cell growth factor by human cytomegalovirus infection of fibroblasts

1 Unité d'Immunologie Virale, Department des Rétrovirus and 2 Unité de Biotechnologie Cellulaire, Institut Pasteur, 28, rue du Dr Roux, Paris Cédex 15, France Human cytomegalovirus (HCMV) induction of growth factors in fibroblasts was investigated after establishing serum-free culture condition...

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Bibliographic Details
Published in:Journal of general virology 1991-11, Vol.72 (11), p.2765-2770
Main Authors: Alcami, Jose, Barzu, Teresa, Michelson, Susan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Division
Cytomegalovirus - physiology
Endothelium, Vascular - cytology
Fibroblast Growth Factor 2 - biosynthesis
Fibroblasts - metabolism
Fibroblasts - microbiology
Fundamental and applied biological sciences. Psychology
Heparin - pharmacology
Humans
Insulin - pharmacology
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Thymidine - metabolism
Transferrin - pharmacology
Virology
Virus Replication
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Summary:1 Unité d'Immunologie Virale, Department des Rétrovirus and 2 Unité de Biotechnologie Cellulaire, Institut Pasteur, 28, rue du Dr Roux, Paris Cédex 15, France Human cytomegalovirus (HCMV) induction of growth factors in fibroblasts was investigated after establishing serum-free culture conditions conducive to viral replication. HCMV infection induced a type II heparin-binding growth factor which stimulated human endothelial cell proliferation. Present address: Sanofi Recherche, Centre Choay, 94258 Gentilly Cédex 30, France. Received 22 April 1991; accepted 8 July 1991.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-72-11-2765