Continuous Neostigmine Infusion in Post-Thymectomy Juvenile Myasthenic Crisis

A 10-year-old boy with myasthenia gravis had severe post-thymectomy myasthenic crisis necessitating reintroduction of mechanical ventilation on the 5th day after thymectomy. He did not respond to therapy with oral pyridostigmine, corticosteroids, or high-dose intravenous immunoglobulin. Finally, in...

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Bibliographic Details
Published in:Journal of child neurology 2000-11, Vol.15 (11), p.747-749
Main Authors: Briassoulis, George, Hatzis, Tassos, Liakopoulou, Theodota, Youroukos, Sotiris
Format: Article
Language:English
Subjects:
Child
Cholinesterase Inhibitors - administration & dosage
Humans
Infusions, Intravenous
Male
Myasthenia Gravis - drug therapy
Myasthenia Gravis - surgery
Neostigmine - administration & dosage
Severity of Illness Index
Thymectomy - adverse effects
Treatment Outcome
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Summary:A 10-year-old boy with myasthenia gravis had severe post-thymectomy myasthenic crisis necessitating reintroduction of mechanical ventilation on the 5th day after thymectomy. He did not respond to therapy with oral pyridostigmine, corticosteroids, or high-dose intravenous immunoglobulin. Finally, in addition to the usual supportive care, he was treated successfully with continuous intravenous infusion of neostigmine. Continuous infusion of neostigmine was used for the first time in post-thymectomy myasthenic crisis in a child to the best of our knowledge. (J Child Neurol 2000; 15:747-749).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307380001501106