Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome

Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 microM), a metabolite of the dopamine oxidative pathway, was found to down regulate the expression of angiotensin receptor mRNA in RCSN3 cel...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2000-09, Vol.212 (1-2), p.131-134
Main Authors: Dagnino-Subiabre, A, Marcelain, K, Arriagada, C, Paris, I, Caviedes, P, Caviedes, R, Segura-Aguilar, J
Format: Article
Language:English
Subjects:
Angiotensin II - metabolism
Animals
Cell Line
Dihydrolipoamide Dehydrogenase - genetics
Gene Expression Regulation - drug effects
Indolequinones
Indoles - pharmacology
Metabolites
Neurons - cytology
Neurons - metabolism
Parkinson's disease
Rats
Receptors, Angiotensin - genetics
Receptors, Angiotensin - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Substantia Nigra - cytology
Substantia Nigra - metabolism
Transcription, Genetic - drug effects
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Summary:Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 microM), a metabolite of the dopamine oxidative pathway, was found to down regulate the expression of angiotensin receptor mRNA in RCSN3 cells by 83% (p < 0.05).
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1007129609928