One week eradication regimen for Helicobacter pylori

Although Helicobacter pylori is both a frequent cause of gastritis and an important factor in duodenal ulcer recurrence, no treatment regimen exists that is completely safe and effective. We have studied a short eradication regimen of tripotassium dicitrato bismuthate 120 mg four times daily and amo...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-11, Vol.338 (8777), p.1249-1252
Main Authors: Logan, R.P.H., Gummett, P.A., Misiewicz, J.J., Karim, Q.N., Walker, M.M., Baron, J.H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Amoxicillin
Amoxicillin - administration & dosage
Anti-Ulcer Agents - administration & dosage
Biological and medical sciences
Digestive system
Drug Administration Schedule
Drug Combinations
Drug Resistance, Microbial
Drugs
Dyspepsia
Eradication
Female
Follow-Up Studies
Gastritis
Helicobacter Infections - diagnosis
Helicobacter Infections - drug therapy
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Humans
Male
Medical disorders
Medical research
Medical sciences
Metronidazole
Metronidazole - administration & dosage
Middle Aged
Organometallic Compounds - administration & dosage
Patient Compliance
Patients
Pharmacology. Drug treatments
Pyloric Antrum - microbiology
Time Factors
Ulcers
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Summary:Although Helicobacter pylori is both a frequent cause of gastritis and an important factor in duodenal ulcer recurrence, no treatment regimen exists that is completely safe and effective. We have studied a short eradication regimen of tripotassium dicitrato bismuthate 120 mg four times daily and amoxycillin 500 mg four times daily for seven days with metronidazole 400 mg five times daily for three days (days 5-7). 106 patients with peptic ulceration and non-ulcer dyspepsia, who were also infected with H pylori,were entered into the study. H pylori was successfully eradicated in 76/106 (72%) patients (median follow-up 9·3 months). The rate of eradication was higher among patients with metronidazole-sensitive H pylori (40/43, 93%). In 17/30 patients in whom eradication failed, pretreatment metronidazole-resistant strains were subsequently isolated. Side-effects were mild, the commonest (24/106, 24%) being taste disturbance with metronidazole. A one-week eradication regimen is a safe, effective, cheap, and well-tolerated treatment for metronidazole-sensitive H pylori.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)92111-E