Therapeutic video-assisted thoracoscopic surgical resection of colorectal pulmonary metastases

• Published in: European journal of cardio-thoracic surgery 2000-12, Vol.18 (6), p.671-677
• Main Authors: Landreneau, Rodney J., De Giacomo, Tiziano, Mack, Michael J., Hazelrigg, Steven R., Ferson, Peter F., Keenan, Robert J., Luketich, James D., Yim, Anthony P., Coloni, Giorgio F.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Colorectal carcinoma; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Female; Humans; Lung Neoplasms - mortality; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Lung resection; Male; Middle Aged; Pneumonectomy - methods; Pneumonectomy - statistics & numerical data; Preoperative Care; Prospective Studies; Pulmonary metastases; Survival Analysis; Thoracic Surgery, Video-Assisted - methods; Thoracic Surgery, Video-Assisted - statistics & numerical data; Time Factors
• ISSN: 1010-7940; 1873-734X
• DOI: 10.1016/S1010-7940(00)00580-7

Objective: Careful patient selection is vital when video-assisted thoracoscopic surgical (VATS) therapeutic pulmonary metastasectomy of colorectal carcinoma is considered. Complete resection of all metastatic disease remains a vital concept. We reviewed our VATS experience for therapeutic metastasectomy of peripheral colorectal pulmonary metastases. Methods: Over 90 months, therapeutic VATS metastasectomy was accomplished upon 80 patients with colorectal metastases. Thin cut computed tomography (CT) was central in identifying lesions. The mean interval from primary carcinoma to VATS resection was 41 months (1–156 months; median, 33). A solitary lesion was resected in 60 patients and multiple (2–7) lesions resected in 20 patients. Statistics were obtained using the Student's t-test. Results: No operative mortality or major postoperative complications occurred. The hospital stay was 4.5±2.2 days (range, 1–13). All lesions were resected by VATS, with four conversions to thoracotomy to improve the margins. The mean survival of patients with one lesion was 34.8 months compared with 26.5 months for patients with multiple lesions (P=0.37). The mean survival was 20.5 months when metastases occurred 3 years from primary carcinoma resection (P=0.20). Twenty-five (31%) patients are disease free; with a mean interval of 38.7 (3–84; median, 35) months. Sixty-nine percent (55/80) of patients developed a recurrence: 6/80 (8%) local; 19/80 (24%) regional (same hemithorax away from resection); and 30/80 (38%) distant. The overall survival at 1 year was 81.2%, 48.4% at 3 years and 30.8% at 5 years. Conclusions: Therapeutic VATS resection of colorectal metastases appears efficacious. Preoperative CT can identify peripheral colorectal metastases amenable to VATS. Conversion to thoracotomy is indicated when none of the lesions identified by CT are found or when clear surgical margins are jeopardized.