Analytical considerations for microdialysis sampling

Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2000-12, Vol.45 (2), p.169-188
Main Authors: Davies, Malonne I, Cooper, Joshua D, Desmond, Serenity S, Lunte, Craig E, Lunte, Susan M
Format: Article
Language:English
Subjects:
Animals
Biosensing Techniques
Biosensor
Biosensors
Capillary electrophoresis
Chromatography, High Pressure Liquid
Drug products
Electrochemical detection
Electrophoresis
Electrophoresis, Capillary
Fluorescence detection
Humans
Liquid chromatography
Mass Spectrometry
Microdialysis
Tissue
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Summary:Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the analytical system. Rapid separations can be coupled on-line with microdialysis to provide near real-time data. By combining microdialysis sampling with a liquid chromatographic or capillary electrophoretic separation and a highly sensitive detection method, a separation-based sensor can be developed. Such sensors have been applied to the investigation of drug entities as well as to study endogenous analytes.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(00)00114-9