Does dietary protein intake correlate with markers suggestive of early diabetic nephropathy in children and adolescents with Type 1 diabetes mellitus?

• Published in: Diabetic medicine 2000-10, Vol.17 (10), p.708-712
• Main Authors: O'hayon, B. E., Cummings, E. A., Daneman, D., Ossip, M. G., Lawson, M. L., Sochett, E. B.
• Format: Article
• Language: English
• Subjects: Adolescent; albumin excretion rate; Albuminuria; Associated diseases and complications; Biological and medical sciences; Biomarkers - blood; Biomarkers - urine; Child; Creatinine - blood; Creatinine - urine; Cross-Sectional Studies; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - urine; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - blood; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - urine; diabetic nephropathy; Dietary Proteins; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Glomerular Filtration Rate; Glycated Hemoglobin A - analysis; Humans; Kidney - diagnostic imaging; Male; Medical sciences; nephromegaly; Puberty; Regression Analysis; Ultrasonography; Urea - urine
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1046/j.1464-5491.2000.00366.x

SUMMARY Aims  To examine the relationship between dietary protein intake and possible early markers of diabetic nephropathy (creatinine clearance (CrCl), kidney volume and albumin excretion rate (AER)). Methods  One hundred and forty‐five subjects with diabetes for 5–10 years, divided into three pubertal groups, participated. Kidney volume was measured by ultrasound, and serum creatinine and HbA1c were assayed. Two or three 24‐h urine collections were obtained for albumin, creatinine and urea excretion rates. Dietary protein intake was estimated from urinary urea nitrogen excretion rate. Glomerular filtration rate was estimated by creatinine clearance. Results  Mean protein intake was 1.22 ± 0.48 g.kg−1.day−1 Protein intake was significantly higher in males than females (P