Genetic Ablation and Restoration of the Olfactory Topographic Map

In the olfactory sensory system, neurons expressing a given odorant receptor project with precision to two of 1800 spatially invariant glomeruli creating a topographic map within the olfactory bulb. Olfactory sensory neurons have a half-life of about 90 days and are continually renewing. This poses...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2000-11, Vol.103 (4), p.609-620
Main Authors: Gogos, Joseph A., Osborne, Joseph, Nemes, Adriana, Mendelsohn, Monica, Axel, Richard
Format: Article
Language:English
Subjects:
Animals
Cell Death - genetics
Genetic Engineering - methods
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Regeneration - physiology
Olfactory Bulb - anatomy & histology
Olfactory Bulb - physiology
Olfactory Receptor Neurons - physiology
Receptors, Odorant - physiology
Tissue Distribution
Turbinates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the olfactory sensory system, neurons expressing a given odorant receptor project with precision to two of 1800 spatially invariant glomeruli creating a topographic map within the olfactory bulb. Olfactory sensory neurons have a half-life of about 90 days and are continually renewing. This poses the problem of how this precise spatial map is maintained throughout the life of the organism. We have developed a genetic approach to effect the synchronous ablation of subpopulations of neurons expressing a given receptor. The axons of newly generated neurons can then be followed as they enter the brain and converge on glomerular targets during adult life. The observation that following neuronal cell killing, the spatial map is faithfully restored, demonstrates that the information necessary for the establishment of the sensory map persists throughout the life of the organism.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)00164-1