Activity of Matrix Metalloproteinase-2 and -9 in Abdominal Aortic Aneurysms. Relation to Size and Rupture

Objectives: to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs). Design: cross-sectional study. Materials and methods: MMP-2 and MMP-9 activity was estimated in biopsies from the ant...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2000-11, Vol.20 (5), p.457-461
Main Authors: Petersen, E, Gineitis, A, Wågberg, F, Ängquist, K -A
Format: Article
Language:English
Subjects:
Abdominal aortic aneurysm
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - enzymology
Aortic Aneurysm, Abdominal - pathology
Aortic Rupture - enzymology
Cross-Sectional Studies
Female
Humans
Male
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinases
Middle Aged
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Summary:Objectives: to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs). Design: cross-sectional study. Materials and methods: MMP-2 and MMP-9 activity was estimated in biopsies from the anterior wall of 60 AAAs using gelatin zymography. There were 20 medium-sized (diameter 557 cm) aAAAs and 20 rAAAs. MMP activity was quantified using a laser densitometer and expressed as arbitrary units (au). Results: mean (SEM) MMP-9 activity was significantly lower in large aAAAs (1190 au ±247) than in rAAAs (2647 au ±498, p
ISSN:1078-5884
1532-2165
DOI:10.1053/ejvs.2000.1211