Activity of Matrix Metalloproteinase-2 and -9 in Abdominal Aortic Aneurysms. Relation to Size and Rupture

Objectives: to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs). Design: cross-sectional study. Materials and methods: MMP-2 and MMP-9 activity was estimated in biopsies from the ant...

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Published in:European journal of vascular and endovascular surgery 2000-11, Vol.20 (5), p.457-461
Main Authors: Petersen, E, Gineitis, A, Wågberg, F, Ängquist, K -A
Format: Article
Language:English
Subjects:
Abdominal aortic aneurysm
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - enzymology
Aortic Aneurysm, Abdominal - pathology
Aortic Rupture - enzymology
Cross-Sectional Studies
Female
Humans
Male
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinases
Middle Aged
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cited_by cdi_FETCH-LOGICAL-c446t-235bb5e77e4d4293d40c7e2083b5cfffdd6d8606474b6b90ccae80df1d1e0ca93
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container_issue 5
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container_title European journal of vascular and endovascular surgery
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creator Petersen, E
Gineitis, A
Wågberg, F
Ängquist, K -A
description Objectives: to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs). Design: cross-sectional study. Materials and methods: MMP-2 and MMP-9 activity was estimated in biopsies from the anterior wall of 60 AAAs using gelatin zymography. There were 20 medium-sized (diameter 557 cm) aAAAs and 20 rAAAs. MMP activity was quantified using a laser densitometer and expressed as arbitrary units (au). Results: mean (SEM) MMP-9 activity was significantly lower in large aAAAs (1190 au ±247) than in rAAAs (2647 au ±498, p
doi_str_mv 10.1053/ejvs.2000.1211
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subjects Abdominal aortic aneurysm
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - enzymology
Aortic Aneurysm, Abdominal - pathology
Aortic Rupture - enzymology
Cross-Sectional Studies
Female
Humans
Male
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinases
Middle Aged
title Activity of Matrix Metalloproteinase-2 and -9 in Abdominal Aortic Aneurysms. Relation to Size and Rupture
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