Significantly different bcl-2 expression profiles in gastric and non-gastric primary extranodal high-grade B-cell lymphomas

• Published in: The Journal of pathology 2000-12, Vol.192 (4), p.470-478
• Main Authors: Cogliatti, Sergio B., Griesser, Henrik, Peng, Huaizheng, Du, Ming-Qing, Isaacson, Peter G., Zimmermann, Dieter R., Maibach, Rudolf C., Schmid, Ulrico
• Format: Article
• Language: English
• Subjects: bcl-2; Biological and medical sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; extranodal high-grade B-cell lymphoma; gastric lymphoma; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Genes, p53; Hematologic and hematopoietic diseases; Humans; Immunoenzyme Techniques; immunohistology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - metabolism; Lymphoma, Non-Hodgkin - genetics; Lymphoma, Non-Hodgkin - metabolism; Medical sciences; molecular pathology; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; p53; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Translocation, Genetic; Tumor Suppressor Protein p53 - metabolism; Tumors
• ISSN: 0022-3417; 1096-9896
• DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH733>3.0.CO;2-U

Fifty‐five cases of primary extranodal high‐grade B‐cell non‐Hodgkin's lymphoma were investigated for bcl‐2 and p53 protein expression as well as for t(14;18) translocations and p53 mutations. Phenotypic and genotypic profiles were compared between tumours of gastric (27 cases) and non‐gastric (28 cases) origin. bcl‐2 protein expression was significantly lower in gastric (11/27) than in non‐gastric (28/28) lymphomas (p