Protein–protein interactions in intracellular membrane fusion

The fusion of intracellular vesicles with their target membranes is an essential feature of the compartmental structure of eukaryotic cells. This process requires proteins that dictate the targeting of a vesicle to the correct cellular location, mediate bilayer fusion and, in some systems, regulate...

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Bibliographic Details
Published in:Current Opinion in Structural Biology 2000-12, Vol.10 (6), p.662-671
Main Authors: Misura, Kira MS, May, Andrew P, Weis, William I
Format: Article
Language:English
Subjects:
ATPase
calcium
coiled-coil
exocytosis
Membrane Fusion
Membrane Proteins - chemistry
Membrane Proteins - metabolism
neurotransmitter
nSec1
Protein Binding
Protein Conformation
SNAREs
syntaxin
Vesicle fusion
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Summary:The fusion of intracellular vesicles with their target membranes is an essential feature of the compartmental structure of eukaryotic cells. This process requires proteins that dictate the targeting of a vesicle to the correct cellular location, mediate bilayer fusion and, in some systems, regulate the precise time at which fusion occurs. Recent biophysical and structural studies of these proteins have begun to provide a foundation for understanding their functions at a molecular level.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00151-2