Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex

The interpretation of task-induced functional imaging of the brain is critically dependent on understanding the relationship between observed blood flow responses and the underlying neuronal changes. However, the exact nature of this neurovascular coupling relationship remains unknown. In particular...

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Bibliographic Details
Published in:Neuroscience 2000-01, Vol.101 (4), p.803-806
Main Authors: Arthurs, O.J, Williams, E.J, Carpenter, T.A, Pickard, J.D, Boniface, S.J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cerebrovascular Circulation
Electric Stimulation
Evoked Potentials, Somatosensory
fMRI
Fundamental and applied biological sciences. Psychology
Humans
Linear Models
Magnetic Resonance Imaging
Male
Median Nerve - physiology
neurovascular coupling
Oxygen - blood
SEP
Somatosensory Cortex - physiology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Vertebrates: nervous system and sense organs
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Summary:The interpretation of task-induced functional imaging of the brain is critically dependent on understanding the relationship between observed blood flow responses and the underlying neuronal changes. However, the exact nature of this neurovascular coupling relationship remains unknown. In particular, it is unclear whether blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) responses principally reflect neuronal synaptic activity. In order to address this issue directly in humans, we measured the increase in somatosensory evoked potential amplitude and fMRI BOLD changes to increases in intensity of median nerve electrical stimulation in five healthy non-anaesthetized subjects. We found that mean N20–P22 amplitudes increased significantly with stimulus intensity in all subjects, as did fMRI BOLD percentage signal intensity change. Moreover, the intensity of the BOLD signal was found to correlate linearly with evoked potential amplitude in four of the five subjects studied. This suggests that the BOLD response correlates with synchronized synaptic activity, which is the major energy consuming process of the cortex.
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(00)00511-X