Adipose tissue engineering: The future of breast and soft tissue reconstruction following tumor resection

Reconstructive surgeons have always been at the forefront of medical technology. The history of reconstructive surgery began with ablative surgery, which was followed by tissue and organ transplantation, leading to contemporary tissue reconstruction. The field of reconstructive surgery is poised at...

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Bibliographic Details
Published in:Seminars in surgical oncology 2000-10, Vol.19 (3), p.302-311
Main Author: Patrick Jr, Charles W.
Format: Article
Language:English
Subjects:
Adipose Tissue
biomedical engineering
Biomedical Engineering - trends
Breast - blood supply
breast implantation
Breast Implants
Breast Neoplasms - surgery
capillaries
Cell Differentiation
Culture Techniques - methods
Female
Humans
Male
Mastectomy
Microcirculation
Neovascularization, Physiologic
reconstructive surgical procedures
Reconstructive Surgical Procedures - methods
Soft Tissue Neoplasms - surgery
Surgical Flaps
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Summary:Reconstructive surgeons have always been at the forefront of medical technology. The history of reconstructive surgery began with ablative surgery, which was followed by tissue and organ transplantation, leading to contemporary tissue reconstruction. The field of reconstructive surgery is poised at the next stage of its evolution, namely tissue regeneration. The field of tissue engineering has largely defined this evolutionary leap. One active area of investigation is the development of tissue engineering strategies for adipose tissue. Bioengineers, life scientists, and reconstructive surgeons are synergistically coupling expertise in areas such as cell culture technology, tissue transfer, cell differentiation, angiogenesis, computer modeling, and polymer chemistry to regenerate adipose tissue de novo for breast replacement and soft‐tissue augmentation following tumor resection. This work presents the current state of the art in adipose tissue engineering, as well the clinically translatable strategies currently under development. Semin. Surg. Oncol. 19:302–311, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:8756-0437
1098-2388
DOI:10.1002/1098-2388(200010/11)19:3<302::AID-SSU12>3.0.CO;2-S