Nonplatelet Effects of Aspirin During Acute Coronary Occlusion: Electrophysiologic and Cation Alterations in Ischemic Myocardium

• Published in: Journal of cardiovascular pharmacology and therapeutics 2000-06, Vol.5 (2), p.113-120
• Main Authors: Shehadeh, Abbas A., Arena, Joseph, Moschos, Christos B., Regan, Timothy J.
• Format: Article
• Language: English
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Animals; Aspirin - pharmacology; Coronary Disease - complications; Dogs; Epinephrine - pharmacology; Male; Myocardial Ischemia - complications; Platelet Aggregation Inhibitors - pharmacology; Ventricular Fibrillation - physiopathology; Ventricular Fibrillation - prevention & control
• ISSN: 1074-2484; 1940-4034
• DOI: 10.1053/XV.2000.5492

Background: Mortality after acute myocardial ischemia has been reduced by aspirin (ASA) but mechanisms other than the antiplatelet effect have not been established. This article evaluates an antiarrhythmic action during sympathetic stimulation in the intact anesthetized dog with and without ischemia. Methods and Results: The ventricular fibrillation threshold (VFT) was examined before and after epinephrine (E) in normals (group I). A VFT reduction during E was normalized after 1 week of ASA (P < .01). Regional myocardial ischemia for I hour resulted in similar hypoperfusion in controls of group II and after ASA. Action potential responses in isolated superfused ischemic tissue showed prolonged repolarization (APD90) in response to E, which was normalized after ASA (P < .01). To assess the antiarrhythmic role of the anion in group III, Na salicylate was given. During 1 hour of ischemia, the VF incidence was reduced and cation abnormalities diminished in ischemic myocardium compared with untreated ischemia. Conclusions: ASA antagonizes the reduction of the VFT induced by catecholamine in nor mals as well as the repolarization abnormality elicited by E during acute ischemia. The salicylate anion appears to be the active component in view of the efficacy in preventing VF during the early ischemic period.