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The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats
Ultraviolet A (UVA) light exposed cells can induce the production of reactive oxygen species (ROS) which can damage the cellular elements. Antioxidants can interfere with the production of ROS. In this study, malondialdehyde (MDA), reduced glutathione (GSH), glutathione reductase (GSSGR), glutathion...
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| Published in: | Toxicology (Amsterdam) 2000-11, Vol.154 (1), p.21-29 |
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| Language: | English |
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| container_title | Toxicology (Amsterdam) |
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| creator | Erden Inal, Mine Kahraman, Ahmet |
| description | Ultraviolet A (UVA) light exposed cells can induce the production of reactive oxygen species (ROS) which can damage the cellular elements. Antioxidants can interfere with the production of ROS. In this study, malondialdehyde (MDA), reduced glutathione (GSH), glutathione reductase (GSSGR), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels were measured in the liver of rats exposed to UVA light in various doses. The effects of quercetin were determined as antioxidant on those parameters. Rats were divided into three groups as control, ultraviolet (UV), and ultraviolet+quercetin (UV+Q). UV and UV+Q group rats were irradiated 4 h per day with UVA light (1.25 mW/cm
2) during periods of 0,
3,
6,
9 days. Thus, on days 0,
3,
6 and 9, the rats have received 0,
54,
108,
162 W/cm
2 light, respectively. Quercetin (50 mg/kg body wt.) was administered intraperitoneally before each irradiation period in the UV+Q group rats. MDA level in the UV group increased significantly on day-9 when compared to the control group (
P |
| doi_str_mv | 10.1016/S0300-483X(00)00268-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72474258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0300483X00002687</els_id><sourcerecordid>17750665</sourcerecordid><originalsourceid>FETCH-LOGICAL-e353t-51baaee5ba59e969b3d7b9a13e739b06516a3887a7dad0d5658c1b43f7bcde2c3</originalsourceid><addsrcrecordid>eNqF0c9rFTEQB_AgFvus_gmWgCD2sG2y2fzYk0jRWij00ArewiSZtZF9uzXJPup_37zXZ6-dywTyYUjmS8gHzk454-rshgnGms6IX58ZO2GsVabRr8iKG903ghv5mqyeySF5m_MfVpXo1BtyyGsZpfSKuNs7pPdpLuhL3CDFYagnOg90GGEzT_NI_y6YPJY4UfgNccqFLmNJsInziIUCjVNYPAY6P8QAuyG5JMy5XtAEJb8jBwOMGd_v-xH5-f3b7fmP5ur64vL861WDQorSSO4AEKUD2WOveieCdj1wgVr0jinJFQhjNOgAgQWppPHcdWLQzgdsvTgin57m1u_UN-di1zF7HEeYcF6y1W2nu1aaFyHXWjKl5Muwk7X4Fh7v4eLWGOx9imtI_-z_PVfwcQ8gexiHBJOP-dmZ1vBWVfXlSWFd0yZistlHnOpyY6qp2DBHy5nd5m93-dttuLb2Xf5Wi0dIR6K0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14555515</pqid></control><display><type>article</type><title>The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Erden Inal, Mine ; Kahraman, Ahmet</creator><creatorcontrib>Erden Inal, Mine ; Kahraman, Ahmet</creatorcontrib><description><![CDATA[Ultraviolet A (UVA) light exposed cells can induce the production of reactive oxygen species (ROS) which can damage the cellular elements. Antioxidants can interfere with the production of ROS. In this study, malondialdehyde (MDA), reduced glutathione (GSH), glutathione reductase (GSSGR), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels were measured in the liver of rats exposed to UVA light in various doses. The effects of quercetin were determined as antioxidant on those parameters. Rats were divided into three groups as control, ultraviolet (UV), and ultraviolet+quercetin (UV+Q). UV and UV+Q group rats were irradiated 4 h per day with UVA light (1.25 mW/cm
2) during periods of 0,
3,
6,
9 days. Thus, on days 0,
3,
6 and 9, the rats have received 0,
54,
108,
162 W/cm
2 light, respectively. Quercetin (50 mg/kg body wt.) was administered intraperitoneally before each irradiation period in the UV+Q group rats. MDA level in the UV group increased significantly on day-9 when compared to the control group (
P<0.05). The MDA levels in the UV+Q group decreased significantly on day-6 and 9 in comparison with the UV group (
P<0.05,
P<0.001, respectively). GSH levels in all groups were not significantly different. GSSGR and GPx activities in the UV group were significantly lower on day-6 and 9 than in the control group (
P<0.001). On all days these enzyme activities in the UV+Q group were significantly higher than in the UV group and higher than in the control group (
P<0.001). SOD and CAT activities in the UV group decreased significantly on day-3, 6, and 9 in comparison with the control group (
P<0.001). These enzyme activities also increased significantly in the UV+Q group on all days when compared to the UV group (
P<0.001). This study demonstrated that the exposure of rats to UVA led to oxidative stress as reflected by increased MDA levels and reduced enzymic antioxidant levels, quercetin may be useful by reducing or preventing photobiologic damage.]]></description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(00)00268-7</identifier><identifier>PMID: 11118667</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Catalase - analysis ; Cell metabolism, cell oxidation ; Cell physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Glutathione - analysis ; Glutathione Peroxidase - analysis ; Glutathione Reductase - analysis ; Lipid Peroxides - biosynthesis ; Liver - enzymology ; Malondialdehyde - analysis ; Molecular and cellular biology ; Oxidative stress ; Oxidative Stress - drug effects ; Quercetin ; Quercetin - pharmacology ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase - analysis ; Ultraviolet Rays - adverse effects ; UVA</subject><ispartof>Toxicology (Amsterdam), 2000-11, Vol.154 (1), p.21-29</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=828126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11118667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erden Inal, Mine</creatorcontrib><creatorcontrib>Kahraman, Ahmet</creatorcontrib><title>The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description><![CDATA[Ultraviolet A (UVA) light exposed cells can induce the production of reactive oxygen species (ROS) which can damage the cellular elements. Antioxidants can interfere with the production of ROS. In this study, malondialdehyde (MDA), reduced glutathione (GSH), glutathione reductase (GSSGR), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels were measured in the liver of rats exposed to UVA light in various doses. The effects of quercetin were determined as antioxidant on those parameters. Rats were divided into three groups as control, ultraviolet (UV), and ultraviolet+quercetin (UV+Q). UV and UV+Q group rats were irradiated 4 h per day with UVA light (1.25 mW/cm
2) during periods of 0,
3,
6,
9 days. Thus, on days 0,
3,
6 and 9, the rats have received 0,
54,
108,
162 W/cm
2 light, respectively. Quercetin (50 mg/kg body wt.) was administered intraperitoneally before each irradiation period in the UV+Q group rats. MDA level in the UV group increased significantly on day-9 when compared to the control group (
P<0.05). The MDA levels in the UV+Q group decreased significantly on day-6 and 9 in comparison with the UV group (
P<0.05,
P<0.001, respectively). GSH levels in all groups were not significantly different. GSSGR and GPx activities in the UV group were significantly lower on day-6 and 9 than in the control group (
P<0.001). On all days these enzyme activities in the UV+Q group were significantly higher than in the UV group and higher than in the control group (
P<0.001). SOD and CAT activities in the UV group decreased significantly on day-3, 6, and 9 in comparison with the control group (
P<0.001). These enzyme activities also increased significantly in the UV+Q group on all days when compared to the UV group (
P<0.001). This study demonstrated that the exposure of rats to UVA led to oxidative stress as reflected by increased MDA levels and reduced enzymic antioxidant levels, quercetin may be useful by reducing or preventing photobiologic damage.]]></description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catalase - analysis</subject><subject>Cell metabolism, cell oxidation</subject><subject>Cell physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione - analysis</subject><subject>Glutathione Peroxidase - analysis</subject><subject>Glutathione Reductase - analysis</subject><subject>Lipid Peroxides - biosynthesis</subject><subject>Liver - enzymology</subject><subject>Malondialdehyde - analysis</subject><subject>Molecular and cellular biology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Superoxide Dismutase - analysis</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>UVA</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqF0c9rFTEQB_AgFvus_gmWgCD2sG2y2fzYk0jRWij00ArewiSZtZF9uzXJPup_37zXZ6-dywTyYUjmS8gHzk454-rshgnGms6IX58ZO2GsVabRr8iKG903ghv5mqyeySF5m_MfVpXo1BtyyGsZpfSKuNs7pPdpLuhL3CDFYagnOg90GGEzT_NI_y6YPJY4UfgNccqFLmNJsInziIUCjVNYPAY6P8QAuyG5JMy5XtAEJb8jBwOMGd_v-xH5-f3b7fmP5ur64vL861WDQorSSO4AEKUD2WOveieCdj1wgVr0jinJFQhjNOgAgQWppPHcdWLQzgdsvTgin57m1u_UN-di1zF7HEeYcF6y1W2nu1aaFyHXWjKl5Muwk7X4Fh7v4eLWGOx9imtI_-z_PVfwcQ8gexiHBJOP-dmZ1vBWVfXlSWFd0yZistlHnOpyY6qp2DBHy5nd5m93-dttuLb2Xf5Wi0dIR6K0</recordid><startdate>20001123</startdate><enddate>20001123</enddate><creator>Erden Inal, Mine</creator><creator>Kahraman, Ahmet</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>7X8</scope></search><sort><creationdate>20001123</creationdate><title>The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats</title><author>Erden Inal, Mine ; Kahraman, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e353t-51baaee5ba59e969b3d7b9a13e739b06516a3887a7dad0d5658c1b43f7bcde2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catalase - analysis</topic><topic>Cell metabolism, cell oxidation</topic><topic>Cell physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione - analysis</topic><topic>Glutathione Peroxidase - analysis</topic><topic>Glutathione Reductase - analysis</topic><topic>Lipid Peroxides - biosynthesis</topic><topic>Liver - enzymology</topic><topic>Malondialdehyde - analysis</topic><topic>Molecular and cellular biology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Superoxide Dismutase - analysis</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>UVA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erden Inal, Mine</creatorcontrib><creatorcontrib>Kahraman, Ahmet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erden Inal, Mine</au><au>Kahraman, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2000-11-23</date><risdate>2000</risdate><volume>154</volume><issue>1</issue><spage>21</spage><epage>29</epage><pages>21-29</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract><![CDATA[Ultraviolet A (UVA) light exposed cells can induce the production of reactive oxygen species (ROS) which can damage the cellular elements. Antioxidants can interfere with the production of ROS. In this study, malondialdehyde (MDA), reduced glutathione (GSH), glutathione reductase (GSSGR), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels were measured in the liver of rats exposed to UVA light in various doses. The effects of quercetin were determined as antioxidant on those parameters. Rats were divided into three groups as control, ultraviolet (UV), and ultraviolet+quercetin (UV+Q). UV and UV+Q group rats were irradiated 4 h per day with UVA light (1.25 mW/cm
2) during periods of 0,
3,
6,
9 days. Thus, on days 0,
3,
6 and 9, the rats have received 0,
54,
108,
162 W/cm
2 light, respectively. Quercetin (50 mg/kg body wt.) was administered intraperitoneally before each irradiation period in the UV+Q group rats. MDA level in the UV group increased significantly on day-9 when compared to the control group (
P<0.05). The MDA levels in the UV+Q group decreased significantly on day-6 and 9 in comparison with the UV group (
P<0.05,
P<0.001, respectively). GSH levels in all groups were not significantly different. GSSGR and GPx activities in the UV group were significantly lower on day-6 and 9 than in the control group (
P<0.001). On all days these enzyme activities in the UV+Q group were significantly higher than in the UV group and higher than in the control group (
P<0.001). SOD and CAT activities in the UV group decreased significantly on day-3, 6, and 9 in comparison with the control group (
P<0.001). These enzyme activities also increased significantly in the UV+Q group on all days when compared to the UV group (
P<0.001). This study demonstrated that the exposure of rats to UVA led to oxidative stress as reflected by increased MDA levels and reduced enzymic antioxidant levels, quercetin may be useful by reducing or preventing photobiologic damage.]]></abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>11118667</pmid><doi>10.1016/S0300-483X(00)00268-7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Toxicology (Amsterdam), 2000-11, Vol.154 (1), p.21-29 |
| issn | 0300-483X 1879-3185 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Biological and medical sciences Catalase - analysis Cell metabolism, cell oxidation Cell physiology Female Fundamental and applied biological sciences. Psychology Glutathione - analysis Glutathione Peroxidase - analysis Glutathione Reductase - analysis Lipid Peroxides - biosynthesis Liver - enzymology Malondialdehyde - analysis Molecular and cellular biology Oxidative stress Oxidative Stress - drug effects Quercetin Quercetin - pharmacology Rats Rats, Sprague-Dawley Superoxide Dismutase - analysis Ultraviolet Rays - adverse effects UVA |
| title | The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats |
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