Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension

We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37±4 years) were classified prospectively into 2 groups on the basis of having eit...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-12, Vol.36 (6), p.929-933
Main Authors: Toikka, Jyri O, Laine, Hanna, Ahotupa, Markku, Haapanen, Arto, Viikari, Jorma S. A, Hartiala, Jaakko J, Raitakari, Olli T
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelium, Vascular - physiopathology
Humans
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Lipoproteins, LDL - metabolism
Male
Medical sciences
Oxidation-Reduction
Prospective Studies
Tunica Intima - pathology
Tunica Media - pathology
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Summary:We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37±4 years) were classified prospectively into 2 groups on the basis of having either borderline hypertension (systolic 130 to 140 mm Hg or diastolic 85 to 89 mm Hg, n=16) or normal (
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.36.6.929