Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog

We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atria...

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Bibliographic Details
Published in:European journal of heart failure 2000-12, Vol.2 (4), p.379-386
Main Authors: Luchner, Andreas, Borgeson, Daniel D., Grantham, James A., Friedrich, Erik, Riegger, Günter A.J., Burnett Jr, John C., Redfield, Margaret M.
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - genetics
Atrial Natriuretic Factor - metabolism
Cardiac Pacing, Artificial
Dog
Dogs
Gene
Gene Expression
Heart Failure - etiology
Heart Failure - physiopathology
LV hypertrophy
Male
Pacing
Time Factors
Ventricular Dysfunction, Left - physiopathology
Ventricular Remodeling - physiology
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Summary:We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30% and +6%, respectively, P
ISSN:1388-9842
1879-0844
DOI:10.1016/S1388-9842(00)00104-5