Rhodococcus equi and HIV-1 Infection in Uganda

Objectives: To describe three cases of Rhodococcus equi infection in a cohort of HIV-1 infected adults in Entebbe, Uganda and to compare this to the rates and presentation of tuberculosis in this cohort. Methods: Consecutive HIV-1 infected adults registering with a community HIV/AIDS clinic in Enteb...

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Bibliographic Details
Published in:The Journal of infection 2000-11, Vol.41 (3), p.227-231
Main Authors: Gray, K.J., French, N., Lugada, E., Watera, C., Gilks, C.F.
Format: Article
Language:English
Subjects:
Actinomycetales Infections - diagnosis
Actinomycetales Infections - epidemiology
Adult
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - epidemiology
Biological and medical sciences
CD4 Lymphocyte Count
Cohort Studies
Diagnosis, Differential
Female
HIV-1
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Rhodococcus equi
Tropical medicine
Tuberculosis - diagnosis
Tuberculosis - epidemiology
Uganda
Uganda - epidemiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Objectives: To describe three cases of Rhodococcus equi infection in a cohort of HIV-1 infected adults in Entebbe, Uganda and to compare this to the rates and presentation of tuberculosis in this cohort. Methods: Consecutive HIV-1 infected adults registering with a community HIV/AIDS clinic in Entebbe were enrolled in a cohort between October 1995 and June 1998 as part of an intervention trial of pneumococcal polysaccharide vaccine. Participants were routinely reviewed every 6 months and had open access to the clinic when unwell. Standard protocols were followed for investigation and management of illness. Microbiological investigations followed standard procedures. Results: 1372 (71% female) study participants were followed for 2141 person years of observation (pyo). Rhodococcus equi was isolated from three study participants from blood, a lymph node aspirate and stool. The individuals were undergoing investigation of acute pneumonia, acute cough with cervical lymphadenopathy and chronic fever with wasting, respectively. The clinical features of these cases are described. All had a CD4 T-cell count of
ISSN:0163-4453
1532-2742
DOI:10.1053/jinf.2000.0730