Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method

Modified nucleosides, formed post‐transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed‐phase high‐pe...

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Bibliographic Details
Published in:Biomedical chromatography 2000-11, Vol.14 (7), p.459-463
Main Authors: Xu, G., Schmid, H. R., Lu, X., Liebich, H. M., Lu, P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - urine
Chromatography, High Pressure Liquid - methods
Factor Analysis, Statistical
Female
Humans
Middle Aged
Nucleosides - urine
Spectrophotometry, Ultraviolet
Citations: Items that this one cites
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Summary:Modified nucleosides, formed post‐transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed‐phase high‐performance liquid chromatographic (RP‐HPLC) method and a factor analysis method have been used to study the excretion pattern of nucleosides of breast cancer patients. A clear cut differentiation of the breast cancer group and the healthy individuals in two clusters without overlapping was obtained. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0269-3879
1099-0801
DOI:10.1002/1099-0801(200011)14:7<459::AID-BMC7>3.0.CO;2-K