A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus

Abstract Because previous studies have shown that a high molecular mass constituent of cranberry juice inhibited adhesion of Escherichia coli to epithelial cells and coaggregation of oral bacteria, we have examined its effect on the adhesion of Helicobacter pylori to immobilized human mucus and to e...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2000-12, Vol.29 (4), p.295-301
Main Authors: Burger, Ora, Ofek, Itzhak, Tabak, Mina, Weiss, Ervin I., Sharon, Nathan, Neeman, Ishak
Format: Article
Language:English
Subjects:
Adhesion
Antibacterial agents
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Bacterial Adhesion
Beverages
Biological and medical sciences
Chemotherapic agents
Constituents
Cranberries
Cranberry
cranberry juice
E coli
Epithelial cells
Erythrocytes
Erythrocytes - microbiology
Fruit - chemistry
Fundamental and applied biological sciences. Psychology
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Helicobacter pylori - physiology
Humans
Juices
Medical sciences
Microbiology
Mucus
Mucus - microbiology
N-Acetylneuraminic Acid
Pharmacology. Drug treatments
Stomach
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Summary:Abstract Because previous studies have shown that a high molecular mass constituent of cranberry juice inhibited adhesion of Escherichia coli to epithelial cells and coaggregation of oral bacteria, we have examined its effect on the adhesion of Helicobacter pylori to immobilized human mucus and to erythrocytes. We employed three strains of H. pylori all of which bound to the mucus and agglutinated human erythrocytes via a sialic acid-specific adhesin. The results showed that a high molecular mass constituent derived from cranberry juice inhibits the sialic acid-specific adhesion of H. pylori to human gastric mucus and to human erythrocytes.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.2000.tb01537.x