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Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia

Objective: The aim of this study was to determine whether plasma concentrations of vascular endothelial growth factor and placental growth factor are altered in women with severe preeclampsia. Study Design: We performed a case-control study to compare plasma concentrations of vascular endothelial gr...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2000-12, Vol.183 (6), p.1554-1557
Main Authors: Livingston, Jeffrey C., Chin, Robert, Haddad, Bassam, McKinney, Elizabeth T., Ahokas, Robert, Sibai, Baha M.
Format: Article
Language:English
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Summary:Objective: The aim of this study was to determine whether plasma concentrations of vascular endothelial growth factor and placental growth factor are altered in women with severe preeclampsia. Study Design: We performed a case-control study to compare plasma concentrations of vascular endothelial growth factor and placental growth factor between women with severe preeclampsia and normotensive women admitted for delivery. Twenty-one women with severe preeclampsia were matched for gestational age and ethnicity with 21 normotensive women. Vascular endothelial growth factor and placental growth factor concentrations were measured with a specific antigen-capture enzyme-linked immunosorbent assay. Results: Women with severe preeclampsia demonstrated significantly lower plasma concentrations of both vascular endothelial growth factor (6.36 ± 3.96 pg/mL vs 18.65 ± 5.98 pg/mL; P
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2000.108022