Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM

The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemoly...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2000-12, Vol.56 (3), p.185-190
Main Authors: Tano, Krister, Grahn-Håkansson, Eva, Holm, Stig E, Hellström, Sten
Format: Article
Language:English
Subjects:
Acute Disease
Agar-overlay
Alpha-hemolytic streptococci
Antibiosis
Bacterial interference
Biological and medical sciences
Child
Child, Preschool
Children
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Haemophilus influenzae - growth & development
Humans
Infant
M. catarrhalis
Male
Medical sciences
Moraxella (Branhamella) catarrhalis - growth & development
Nasopharynx
Nasopharynx - microbiology
Non tumoral diseases
Non-typable H. influenzae
Normal flora
Otitis media
Otitis Media - microbiology
Otitis Media with Effusion - microbiology
Otorhinolaryngology. Stomatology
Recurrence
S. pneumoniae
Streptococcus - isolation & purification
Streptococcus - physiology
Streptococcus pneumoniae - growth & development
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Summary:The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemolytic streptococci (AHS) and OM pathogens were recovered from the tubal orifice in each child. The samples were taken from 20 healthy children under general anesthesia, from 19 children with SOM and 20 children with rAOM. The method used to test the bacterial interference in vitro was a modified agar overlay method. The AHS sampled from the tubal orifice of the healthy children were able to inhibit 92% of the S. peumoniae isolates, 74% of the non-typable H. influenzae isolates and 89% of the M. catarrhalis isolates. The corresponding figures for children with SOM and children with rAOM were: 73% of the S. pneumoniae isolates, 58 and 54% of the non-typable H. influenzae isolates and 86 and 89% of the M. catarrhalis isolates. The AHS from children with SOM and children with rAOM were significantly less capable of inhibiting the S. peumoniae and the H. influenzae isolates ( P
ISSN:0165-5876
1872-8464
DOI:10.1016/S0165-5876(00)00428-6