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Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM
The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemoly...
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| Published in: | International journal of pediatric otorhinolaryngology 2000-12, Vol.56 (3), p.185-190 |
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| container_title | International journal of pediatric otorhinolaryngology |
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| creator | Tano, Krister Grahn-Håkansson, Eva Holm, Stig E Hellström, Sten |
| description | The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemolytic streptococci (AHS) and OM pathogens were recovered from the tubal orifice in each child. The samples were taken from 20 healthy children under general anesthesia, from 19 children with SOM and 20 children with rAOM. The method used to test the bacterial interference in vitro was a modified agar overlay method. The AHS sampled from the tubal orifice of the healthy children were able to inhibit 92% of the
S. peumoniae isolates, 74% of the non-typable
H. influenzae isolates and 89% of the
M. catarrhalis isolates. The corresponding figures for children with SOM and children with rAOM were: 73% of the
S. pneumoniae isolates, 58 and 54% of the non-typable
H. influenzae isolates and 86 and 89% of the
M. catarrhalis isolates. The AHS from children with SOM and children with rAOM were significantly less capable of inhibiting the
S. peumoniae and the
H. influenzae isolates (
P |
| doi_str_mv | 10.1016/S0165-5876(00)00428-6 |
| format | article |
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S. peumoniae isolates, 74% of the non-typable
H. influenzae isolates and 89% of the
M. catarrhalis isolates. The corresponding figures for children with SOM and children with rAOM were: 73% of the
S. pneumoniae isolates, 58 and 54% of the non-typable
H. influenzae isolates and 86 and 89% of the
M. catarrhalis isolates. The AHS from children with SOM and children with rAOM were significantly less capable of inhibiting the
S. peumoniae and the
H. influenzae isolates (
P<0.001). There was no significant difference between the three groups of children regarding inhibitory activity against
M.
catarrhalis. The results suggest that the inhibitory activity of the normal bacterial flora at the tubal orifice against pneumococci and
H. influenzae may be reduced in children with SOM and rAOM.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/S0165-5876(00)00428-6</identifier><identifier>PMID: 11137592</identifier><identifier>CODEN: IPOTDJ</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Acute Disease ; Agar-overlay ; Alpha-hemolytic streptococci ; Antibiosis ; Bacterial interference ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Female ; Haemophilus influenzae - growth & development ; Humans ; Infant ; M. catarrhalis ; Male ; Medical sciences ; Moraxella (Branhamella) catarrhalis - growth & development ; Nasopharynx ; Nasopharynx - microbiology ; Non tumoral diseases ; Non-typable H. influenzae ; Normal flora ; Otitis media ; Otitis Media - microbiology ; Otitis Media with Effusion - microbiology ; Otorhinolaryngology. Stomatology ; Recurrence ; S. pneumoniae ; Streptococcus - isolation & purification ; Streptococcus - physiology ; Streptococcus pneumoniae - growth & development</subject><ispartof>International journal of pediatric otorhinolaryngology, 2000-12, Vol.56 (3), p.185-190</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-aa9ed6f0c4a033ccaad9e40e49b7cbbb7b89c070683a17494b14cb6820faadd63</citedby><cites>FETCH-LOGICAL-c389t-aa9ed6f0c4a033ccaad9e40e49b7cbbb7b89c070683a17494b14cb6820faadd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=828626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11137592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tano, Krister</creatorcontrib><creatorcontrib>Grahn-Håkansson, Eva</creatorcontrib><creatorcontrib>Holm, Stig E</creatorcontrib><creatorcontrib>Hellström, Sten</creatorcontrib><title>Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemolytic streptococci (AHS) and OM pathogens were recovered from the tubal orifice in each child. The samples were taken from 20 healthy children under general anesthesia, from 19 children with SOM and 20 children with rAOM. The method used to test the bacterial interference in vitro was a modified agar overlay method. The AHS sampled from the tubal orifice of the healthy children were able to inhibit 92% of the
S. peumoniae isolates, 74% of the non-typable
H. influenzae isolates and 89% of the
M. catarrhalis isolates. The corresponding figures for children with SOM and children with rAOM were: 73% of the
S. pneumoniae isolates, 58 and 54% of the non-typable
H. influenzae isolates and 86 and 89% of the
M. catarrhalis isolates. The AHS from children with SOM and children with rAOM were significantly less capable of inhibiting the
S. peumoniae and the
H. influenzae isolates (
P<0.001). There was no significant difference between the three groups of children regarding inhibitory activity against
M.
catarrhalis. The results suggest that the inhibitory activity of the normal bacterial flora at the tubal orifice against pneumococci and
H. influenzae may be reduced in children with SOM and rAOM.</description><subject>Acute Disease</subject><subject>Agar-overlay</subject><subject>Alpha-hemolytic streptococci</subject><subject>Antibiosis</subject><subject>Bacterial interference</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Female</subject><subject>Haemophilus influenzae - growth & development</subject><subject>Humans</subject><subject>Infant</subject><subject>M. catarrhalis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Moraxella (Branhamella) catarrhalis - growth & development</subject><subject>Nasopharynx</subject><subject>Nasopharynx - microbiology</subject><subject>Non tumoral diseases</subject><subject>Non-typable H. influenzae</subject><subject>Normal flora</subject><subject>Otitis media</subject><subject>Otitis Media - microbiology</subject><subject>Otitis Media with Effusion - microbiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Recurrence</subject><subject>S. pneumoniae</subject><subject>Streptococcus - isolation & purification</subject><subject>Streptococcus - physiology</subject><subject>Streptococcus pneumoniae - growth & development</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkNFqFDEUhoModq0-ghIQRKGjyUwmyVyVUtQWWvaieh2SM2ecyMxkTLLK-vSd7S5b8Mabk0P48v_hI-Q1Zx854_LT3TLqotZKvmfsA2Oi1IV8QlZcq7LQQoqnZHVETsiLlH4yxhWr6-fkhHNeqbopV-Tv9dR757MPEw0dXd_S2eY-_MApUbeldph7W_Q4hmGbPdCUI845QADwtIthpD3aIfdbCr0f2ojT2XGjf3zu6d0Saaf2n9t4sb59SZ51dkj46nCeku9fPn-7vCpu1l-vLy9uCqh0kwtrG2xlx0BYVlUA1rYNCoaicQqcc8rpBphiUleWK9EIxwU4qUvWLWgrq1Pybp87x_Brgymb0SfAYbAThk0yqhQLXNYLWO9BiCGliJ2Zox9t3BrOzE66eZBudkYNY-ZButkVvDkUbNyI7eOrg-UFeHsAbAI7dNFO4NOR06WW5S7mfE_hIuO3x2gSeJwAWx8RsmmD_89H7gHHH5_A</recordid><startdate>20001222</startdate><enddate>20001222</enddate><creator>Tano, Krister</creator><creator>Grahn-Håkansson, Eva</creator><creator>Holm, Stig E</creator><creator>Hellström, Sten</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20001222</creationdate><title>Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM</title><author>Tano, Krister ; Grahn-Håkansson, Eva ; Holm, Stig E ; Hellström, Sten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-aa9ed6f0c4a033ccaad9e40e49b7cbbb7b89c070683a17494b14cb6820faadd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acute Disease</topic><topic>Agar-overlay</topic><topic>Alpha-hemolytic streptococci</topic><topic>Antibiosis</topic><topic>Bacterial interference</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Female</topic><topic>Haemophilus influenzae - growth & development</topic><topic>Humans</topic><topic>Infant</topic><topic>M. catarrhalis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Moraxella (Branhamella) catarrhalis - growth & development</topic><topic>Nasopharynx</topic><topic>Nasopharynx - microbiology</topic><topic>Non tumoral diseases</topic><topic>Non-typable H. influenzae</topic><topic>Normal flora</topic><topic>Otitis media</topic><topic>Otitis Media - microbiology</topic><topic>Otitis Media with Effusion - microbiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Recurrence</topic><topic>S. pneumoniae</topic><topic>Streptococcus - isolation & purification</topic><topic>Streptococcus - physiology</topic><topic>Streptococcus pneumoniae - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tano, Krister</creatorcontrib><creatorcontrib>Grahn-Håkansson, Eva</creatorcontrib><creatorcontrib>Holm, Stig E</creatorcontrib><creatorcontrib>Hellström, Sten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tano, Krister</au><au>Grahn-Håkansson, Eva</au><au>Holm, Stig E</au><au>Hellström, Sten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2000-12-22</date><risdate>2000</risdate><volume>56</volume><issue>3</issue><spage>185</spage><epage>190</epage><pages>185-190</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><coden>IPOTDJ</coden><abstract>The present study was undertaken to elucidate the inhibitory activity of the normal nasopharyngeal flora against the three most common otitis media (OM) pathogens in healthy children, children with secretory otitis media (SOM) and children with recurrent otitis media (rAOM). Isolates of alpha-hemolytic streptococci (AHS) and OM pathogens were recovered from the tubal orifice in each child. The samples were taken from 20 healthy children under general anesthesia, from 19 children with SOM and 20 children with rAOM. The method used to test the bacterial interference in vitro was a modified agar overlay method. The AHS sampled from the tubal orifice of the healthy children were able to inhibit 92% of the
S. peumoniae isolates, 74% of the non-typable
H. influenzae isolates and 89% of the
M. catarrhalis isolates. The corresponding figures for children with SOM and children with rAOM were: 73% of the
S. pneumoniae isolates, 58 and 54% of the non-typable
H. influenzae isolates and 86 and 89% of the
M. catarrhalis isolates. The AHS from children with SOM and children with rAOM were significantly less capable of inhibiting the
S. peumoniae and the
H. influenzae isolates (
P<0.001). There was no significant difference between the three groups of children regarding inhibitory activity against
M.
catarrhalis. The results suggest that the inhibitory activity of the normal bacterial flora at the tubal orifice against pneumococci and
H. influenzae may be reduced in children with SOM and rAOM.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>11137592</pmid><doi>10.1016/S0165-5876(00)00428-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5876 |
| ispartof | International journal of pediatric otorhinolaryngology, 2000-12, Vol.56 (3), p.185-190 |
| issn | 0165-5876 1872-8464 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Acute Disease Agar-overlay Alpha-hemolytic streptococci Antibiosis Bacterial interference Biological and medical sciences Child Child, Preschool Children Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Female Haemophilus influenzae - growth & development Humans Infant M. catarrhalis Male Medical sciences Moraxella (Branhamella) catarrhalis - growth & development Nasopharynx Nasopharynx - microbiology Non tumoral diseases Non-typable H. influenzae Normal flora Otitis media Otitis Media - microbiology Otitis Media with Effusion - microbiology Otorhinolaryngology. Stomatology Recurrence S. pneumoniae Streptococcus - isolation & purification Streptococcus - physiology Streptococcus pneumoniae - growth & development |
| title | Inhibition of OM pathogens by alpha-hemolytic streptococci from healthy children, children with SOM and children with rAOM |
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